USP14
USP14,全稱為泛素特異性蛋白酶14,是一種去泛素化酶,在細胞內發揮著重要的調控作用。它通過去除泛素分子,調節蛋白質的降解和穩定性,從而影響細胞內的多種生理過程。USP14在多種生物過程中發揮作用,包括細胞增殖、分化和凋亡等。USP14與多種疾病密切相關,如癌癥、神經退行性疾病和代謝性疾病。在癌癥中,USP14的表達異常與腫瘤的發生發展密切相關,因此成為癌癥研究的重要靶點。USP14的過表達可以促進腫瘤細胞的增殖、侵襲和轉移,而抑制USP14的表達則可以抑制腫瘤細胞的生長。USP14在非酒精性脂肪肝的發生發展中也發揮著重要作用,它通過調節脂肪酸合成酶的穩定性,影響脂肪肝的發生發展。目前,針對USP14的藥物研發取得了一定的進展,USP14抑制劑在多種癌癥和代謝性疾病的治療中展現出良好的應用前景。
熱銷產品
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 (USP14) (CSB-EP025704HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
USP14 Recombinant Monoclonal Antibody (CSB-RA200787A0HU)
驗證數據
Flow cytometric analysis of Ubiquitin specific peptidase 14 expression in HepG2 cells using Ubiquitin specific peptidase 14 antibody. Green, isotype control; red, Ubiquitin specific peptidase 14.
Immunocytochemical staining of HepG2 cells with Ubiquitin specific peptidase 14 antibody. Nuclei were stained blue with DAPI; Ubiquitin specific peptidase 14 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using ubiquitin specific peptidase 14 antibody. Total cell lysates (20 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ubiquitin specific peptidase 14 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
USP14 Antibody (CSB-PA025704LA01HU)
驗證數據
Western blot
All lanes: USP14 antibody at 2µg/ml
Lane 1: Hela whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 57, 53, 55 kDa
Observed band size: 57 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA025704LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA025704LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells cells using CSB-PA025704LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
USP14 Antibodies
USP14 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA025704GA01HU | USP14 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA025704LA01HU | USP14 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-RA587609A0HU | USP14 Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
| CSB-RA200787A0HU | USP14 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
USP14 Proteins
USP14 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP025704HU CSB-BP025704HU CSB-MP025704HU CSB-EP025704HU-B |
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 (USP14) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP025704HU | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 (USP14) | E.coli |






