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USP10

USP10,即泛素特異性蛋白酶10,別名 KIAA0190、GC124997。它是一種去泛素化酶(DUBs)家族中的重要成員,主要在細胞質中定位,能夠對多種蛋白質進行去泛素化修飾,從而調控它們的穩定性和功能。USP10的作用機制涉及其酶活性,通過特異性地切割泛素鏈,影響蛋白質的降解和信號轉導。它參與調控細胞增殖、細胞周期、凋亡與自噬等生理過程,并且與多種蛋白質如p53、PCNA、MSH2、Notch及PTEN等的去泛素化有關。USP10在多種腫瘤的發生發展中扮演著重要角色。它可以通過穩定p53蛋白及其定位、調節DNA損傷的敏感性與穩定性、延長PTEN半衰期等方式影響癌癥演進。USP10在宮頸癌、胃癌等癌癥中發揮著抑癌作用,而在乳腺癌中可能具有促癌作用。

熱銷產品

USP10 Antibody (CSB-PA613516LA01HU)

驗證數據

CSB-PA613516LA01HU

Western Blot
Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, A549 whole cell lysate, Rat liver tissue
All lanes: USP10 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 88, 93 kDa
Observed band size: 88 kDa

CSB-PA613516LA01HU

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA613516LA01HU at dilution of 1:100

CSB-PA613516LA01HU

Immunofluorescent analysis of Hela cells using CSB-PA613516LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CSB-PA613516LA01HU

Immunoprecipitating USP10 in A549 whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA613516LA01HU in A549 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA613516LA01HU (8μg) + A549 whole cell lysate (500μg)
Lane 3: A549 whole cell lysate (10μg)

USP10 Antibodies

USP10 for Homo sapiens (Human)

USP10 Proteins

USP10 Proteins for Homo sapiens (Human)