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UCHL1

泛素羧基末端水解酶L1(UCHL1)是人體中一種關鍵功能蛋白,常用別名包括PGP9.5。它在細胞內負責泛素分子的回收與再利用,對維持細胞正常生理活動至關重要,尤其在神經系統中含量豐富,與神經元的生長、修復及存活緊密相關。
UCHL1表達或活性出現異常時,可能引發多種健康問題:在帕金森病、阿爾茨海默病等神經退行性疾病中,它的狀態改變會干擾神經元穩定;而在肺癌、胃癌等惡性腫瘤里,其水平變化也常被觀察到,可能成為疾病診斷或病情監測的參考依據。目前,針對UCHL1的藥物研發已取得初步進展,部分靶向該蛋白的小分子化合物正處于早期臨床研究階段,未來有望為相關疾病治療開辟新路徑。

熱銷產品

Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1), partial (CSB-EP025541HU1)

驗證數據

CSB-EP025541HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

UCHL1 Recombinant Monoclonal Antibody (CSB-RA235431A0HU)

驗證數據

CSB-RA235431A0HU

Flow cytometric analysis of UCHL1 expression in HAP-1 cells using UCHL1 antibody. Green, isotype control; red, UCHL1.

CSB-RA235431A0HU

Immunocytochemical staining of HAP-1 cells with UCHL1 antibody. Nuclei were stained blue with DAPI; UCHL1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

CSB-RA235431A0HU

Western blotting analysis using UCHL1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with UCHL1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

UCHL1 Antibody (CSB-PA004876)

驗證數據

CSB-PA004876

Western Blot analysis of U87 H460 U251 mouse brain cells using UCH-L1 Polyclonal Antibody

Human Protein Gene Product 9.5 (PGP 9.5) ELISA Kit (CSB-E13238h)

驗證數據

CSB-E13238h 標準曲線

貨號:CSB-E13238h

規格:96T/48T

靈敏度:1.56 ng/mL

檢測范圍:6.25 ng/mL-400 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

UCHL1 Antibodies

UCHL1 for Homo sapiens (Human)

UCHL1 Proteins

UCHL1 Proteins for Homo sapiens (Human)

UCHL1 ELISA Kit

UCHL1 ELISA Kit for Homo sapiens (Human)