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Txnip

Txnip,全稱為硫氧還蛋白相互作用蛋白,是一種多功能蛋白,主要通過與硫氧還蛋白(Trx)結合來調節細胞的氧化還原狀態。它也被稱為VDUP-1或TBP-2,屬于α-抑制蛋白家族成員。Txnip在多種生理和病理過程中扮演重要角色,包括糖尿病及其并發癥、動脈粥樣硬化、缺血/再灌注損傷和癌癥等。在正常情況下,Txnip位于細胞核內,當細胞內活性氧(ROS)蓄積增多時,會誘導Txnip穿梭到細胞質或線粒體中,通過與Trx結合,抑制Trx的抗氧化能力,有利于ROS的進一步蓄積。當ROS蓄積到毒性濃度時,可誘發內質網應激與線粒體應激,同時激活NLRP3、ASK1等信號蛋白,最終誘導炎癥的產生或細胞凋亡。研究表明,Txnip的表達失衡與多種疾病的發生發展密切相關。例如,在糖尿病患者體內及慢性高血糖環境下,Txnip的表達明顯增加,提示Txnip水平的升高與糖尿病的發生、發展有密切相關。Txnip也可與NLRP3炎性體結合,通過依賴于NLRP3-ASC-caspase-1途徑刺激IL-1β的分泌,誘導炎癥的產生或胰島細胞凋亡。目前,Txnip作為氧化應激效應途徑中的一個關鍵的調控蛋白,已成為評價糖尿病及其并發癥、動脈粥樣硬化、肝細胞缺血/再灌注損傷等疾病的藥物療效的重要靶蛋白。在藥物研發方面,已有針對Txnip的抑制劑(如TIX100、維拉帕米)正在被探索用于治療1型糖尿病。此外,研究提示靶向Txnip或其相關通路(如代謝)可能成為增強ADT敏感性或克服抵抗的新策略。

熱銷產品

Recombinant Thioredoxin-interacting protein (TXNIP) (CSB-CF880966HU)

驗證數據

CSB-CF880966HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TXNIP Recombinant Monoclonal Antibody (CSB-RA949793A0HU)

驗證數據

CSB-RA949793A0HU

Western Blot
Positive WB detected in: THP-1 whole cell lysate(30μg), K562 whole cell lysate(30μg)
All lanes: TXNIP antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 44 kDa kDa
Observed band size: 53 kDa kDa
Exposure time:2min

CSB-RA949793A0HU

IHC image of CSB-RA949793A0HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA949793A0HU

Overlay Peak curve showing K562 cells stained with CSB-RA949793A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

TXNIP Antibody (CSB-PA880966LA01HU)

驗證數據

CSB-PA880966LA01HU

Immunofluorescence staining of MCF-7 cells with CSB-PA880966LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Thioredoxin-interacting protein(TXNIP) ELISA kit (CSB-EL025383HU)

驗證數據

CSB-EL025383HU 標準曲線

貨號:CSB-EL025383HU

規格:96T/48T

靈敏度:3.9 pg/mL

檢測范圍:15.6 pg/mL-1000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Txnip Antibodies

Txnip for Mus musculus (Mouse)

Txnip for Homo sapiens (Human)

Txnip Proteins

Txnip Proteins for Sus scrofa (Pig)

Txnip Proteins for Rattus norvegicus (Rat)

Txnip Proteins for Pongo abelii (Sumatran orangutan)

Txnip Proteins for Mus musculus (Mouse)

Txnip Proteins for Homo sapiens (Human)

Txnip Proteins for Homo sapiens(Human)

Txnip ELISA Kit

Txnip ELISA Kit for Homo sapiens (Human)

Txnip ELISA Kit for Mus musculus (Mouse)

Txnip ELISA Kit for Rattus norvegicus (Rat)