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TSLP

TSLP,全稱胸腺基質(zhì)淋巴細胞生成素,是一種由上皮細胞等多種細胞分泌的細胞因子,在免疫調(diào)節(jié)中扮演重要角色。它主要由上皮細胞、氣道平滑肌細胞、角質(zhì)形成細胞等分泌,能夠分化2型細胞中幼稚的CD4+T淋巴細胞,產(chǎn)生IL-4、IL-5、IL-13,并降低與1型細胞相關(guān)的γ干擾素(IFN-γ)的表達,對多種細胞產(chǎn)生影響。TSLP的異常表達與多種免疫相關(guān)疾病的發(fā)生和發(fā)展密切相關(guān),如過敏性哮喘、特應(yīng)性皮炎和過敏性鼻炎等過敏性疾病,以及類風(fēng)濕性關(guān)節(jié)炎和系統(tǒng)性紅斑狼瘡等自身免疫性疾病。TSLP被證實與多種過敏性疾病有關(guān),包括特應(yīng)性皮炎、支氣管哮喘、嗜酸性粒細胞食管炎等。此外,TSLP還與慢性炎癥性疾病,如慢性阻塞性肺病和乳糜瀉,以及牛皮癬、類風(fēng)濕性關(guān)節(jié)炎等自身免疫疾病有關(guān)。
TSLP靶向藥不僅具有廣譜的特點,能夠有效針對多個適應(yīng)癥,而且其針對的適應(yīng)癥還具備影響廣、病程長的特點,具有極高的商業(yè)價值。在適應(yīng)癥上以治療哮喘居多,但是隨著深入的研究,在乳腺癌、白血病治療等方面也顯示靶點優(yōu)勢。

熱銷產(chǎn)品

Recombinant Macaca fascicularis Thymic stromal lymphopoietin (TSLP) (R127A,R130S) (Active) (CSB-MP5042MOV(M))

驗證數(shù)據(jù)

CSB-MP5042MOV(M)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP5042MOV(M)

Activity
Loaded Cynomolgus TSLP(R127A, R130S) on 96-Flat plate, can bind anti-TSLP antibody(CSB-RA025141MA1HU), with an affinity constant of 4.41 nM as determined in BLI assay (Gator Prime).

CSB-MP5042MOV(M)

Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis TSLP(R127A,R130S) at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC50 is 45.77-53.37 ng/mL.

Recombinant Human Thymic stromal lymphopoietin (TSLP) (R127A,R130A) (Active) (CSB-MP025141HU(M))

驗證數(shù)據(jù)

CSB-MP025141HU(M)

Activity
Measured by its binding ability in a functional ELISA. Immobilized human TSLP(R127A,R130A) at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC50 is 52.55-58.67 ng/mL.

CSB-MP025141HU(M)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP025141HU(M)

The purity of TSLP was greater than 95% as determined by SEC-HPLC

TSLP Recombinant Monoclonal Antibody (CSB-RA025141MA1HU)

驗證數(shù)據(jù)

CSB-RA025141MA1HU

IHC image of CSB-RA025141MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Human thymic stromal lymphopoietin,TSLP ELISA Kit (CSB-E09316h)

驗證數(shù)據(jù)

CSB-E09316h 標(biāo)準(zhǔn)曲線

貨號:CSB-E09316h

規(guī)格:96T/48T

靈敏度:0.078 ng/ml

檢測范圍:0.312 ng/ml-20 ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TSLP Antibodies

TSLP for Homo sapiens (Human)

TSLP Proteins

TSLP Proteins for Homo sapiens (Human)

TSLP Proteins for Mus musculus (Mouse)

TSLP ELISA Kit

TSLP ELISA Kit for Homo sapiens (Human)

TSLP ELISA Kit for Mus musculus (Mouse)



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