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TP63

TP63,即腫瘤蛋白63,是一種在多種腫瘤中表達的p53家族成員。它來源于p53基因的替代剪接,具有多種剪接變體,通過不同的剪接事件產(chǎn)生。TP63的作用機制涉及細胞周期調(diào)控、細胞凋亡、DNA損傷反應(yīng)和細胞分化等過程。它通過與DNA結(jié)合和激活或抑制特定基因的轉(zhuǎn)錄來發(fā)揮其生物學功能。TP63參與的信號通路包括p53信號通路、Wnt/β-catenin信號通路和TGF-β信號通路等。在生物學上,TP63對維持組織再生能力、促進細胞分化和抑制腫瘤發(fā)展具有重要意義。其功能異常可能與多種疾病的發(fā)生發(fā)展相關(guān),是腫瘤治療和組織再生研究中的一個重要靶點。

熱銷產(chǎn)品

Recombinant Human Tumor protein 63 (TP63) (CSB-EP887971HU)

驗證數(shù)據(jù)

CSB-EP887971HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TP63 Recombinant Monoclonal Antibody (CSB-RA887971A0HU)

驗證數(shù)據(jù)

CSB-RA887971A0HU

Western Blot
Positive WB detected in: PC3 whole cell lysate
All lanes: TP63 antibody at 2.1μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 66, 63, 52, 56, 45, 58, 47, 68, 57, 77 KDa
Observed band size: 77 KDa

CSB-RA887971A0HU

IHC image of CSB-RA887971A0HU diluted at 1:210 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

TP63 Antibodies

TP63 for Homo sapiens (Human)

TP63 Proteins

TP63 Proteins for Mus musculus (Mouse)

TP63 Proteins for Rattus norvegicus (Rat)

TP63 Proteins for Homo sapiens (Human)



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