TNIK
TNIK，即TRAF2和NCK相互作用激酶，是一種屬于胚中心激酶家族的蛋白。它在多種生物學(xué)過程中發(fā)揮作用，包括細(xì)胞骨架的構(gòu)建、神經(jīng)樹突細(xì)胞的伸展以及胚胎發(fā)育。TNIK的作用機(jī)制涉及與多種信號(hào)通路的交互，尤其是Wnt/β-catenin信號(hào)通路，其中TNIK作為β-catenin/TCF4轉(zhuǎn)錄復(fù)合物的一部分，對(duì)Wnt靶基因的轉(zhuǎn)錄激活至關(guān)重要。此外，TNIK還參與調(diào)控TGFβ/SMAD信號(hào)通路，影響細(xì)胞的上皮-間質(zhì)轉(zhuǎn)化（EMT）和腫瘤細(xì)胞的轉(zhuǎn)移。在生物學(xué)意義上，TNIK在組織再生、免疫反應(yīng)以及腫瘤發(fā)展中扮演關(guān)鍵角色，是許多疾病包括纖維化疾病和某些癌癥的潛在治療靶點(diǎn)。
熱銷產(chǎn)品
TNIK Antibody (CSB-PA023998LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA023998LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023998LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA023998LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TNIK Antibodies
TNIK for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023998LA01HU | TNIK Antibody | Human | ELISA, IHC, IF |
| CSB-PA023998LB01HU | TNIK Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023998LC01HU | TNIK Antibody, FITC conjugated | Human | |
| CSB-PA023998LD01HU | TNIK Antibody, Biotin conjugated | Human | ELISA |
TNIK Proteins
TNIK Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP890916HU CSB-EP890916HU CSB-BP890916HU CSB-MP890916HU CSB-EP890916HU-B |
Recombinant Human TRAF2 and NCK-interacting protein kinase (TNIK), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
