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TNFSF12

TNFSF12全稱為腫瘤壞死因子超家族成員12，常被稱為TWEAK或APO3L。這一蛋白廣泛表達于免疫細胞中，通過與細胞表面受體FN14結合，觸發炎癥反應、細胞增殖或凋亡，并參與調控組織修復、血管生成及免疫調節等過程。研究發現，其在慢性炎癥性疾病中異常活躍，例如系統性紅斑狼瘡、類風濕性關節炎患者體內TWEAK水平顯著升高。此外，TNFSF12與腫瘤微環境密切相關，可促進某些癌癥的侵襲轉移，同時與神經退行性疾病如多發性硬化、阿爾茨海默病的病理進展存在關聯。
近年來，針對TWEAK-FN14軸的治療策略成為研究熱點。例如，單克隆抗體類藥物通過阻斷兩者結合，已在動物模型中顯示出抑制腫瘤生長和減輕炎癥損傷的效果。部分小分子抑制劑也進入臨床前研究階段，嘗試用于治療自身免疫性疾病和纖維化病癥。其在心血管疾病中的作用存在爭議，既有研究提示可能加重動脈粥樣硬化，也有證據表明適度表達可促進血管再生，這種雙重特性使藥物研發需精準把控干預時機與劑量。

熱銷產品

Recombinant Human Tumor necrosis factor ligand superfamily member 12 (TNFSF12), partial (CSB-EP023987HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TNFSF12 Antibody (CSB-PA023987ESR1HU)

驗證數據

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA023987ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human epityphlon tissue using CSB-PA023987ESR1HU at dilution of 1:100

TNFSF12 Antibody

TNFSF12 Protein

TNFSF12 ELISA Kit

TNFSF12 Antibodies

TNFSF12 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA023987GA01HU	TNFSF12 Antibody	Human,Mouse,Rat	ELISA
CSB-PA023987ESR1HU	TNFSF12 Antibody	Human	ELISA, IHC
CSB-PA152148	TNFSF12 Antibody	Human,Mouse	ELISA,WB,IHC,IF
CSB-PA004351	TNFSF12 Antibody	Human,Mouse	WB, IHC, IF, ELISA
CSB-PA023987LA01HU	TNFSF12 Antibody	Human	ELISA, IHC, IF
CSB-PA023987LD01HU	TNFSF12 Antibody, Biotin conjugated	Human	ELISA

TNFSF12 Proteins

TNFSF12 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP023987HU CSB-BP023987HU CSB-MP023987HU CSB-EP023987HU-B	Recombinant Human Tumor necrosis factor ligand superfamily member 12 (TNFSF12), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023987HU(A4)	Recombinant Human Tumor necrosis factor ligand superfamily member 12 (TNFSF12)	in vitro E.coli expression system
CSB-EP023987HU	Recombinant Human Tumor necrosis factor ligand superfamily member 12 (TNFSF12), partial	E.coli