TNFRSF9
TNFRSF9，即腫瘤壞死因子受體超家族成員9，別名CD137、4-1BB，是一種I型跨膜蛋白，屬于腫瘤壞死因子受體超家族，主要表達(dá)于活化的T細(xì)胞表面，也在B細(xì)胞、單核細(xì)胞和多種轉(zhuǎn)化細(xì)胞系中有表達(dá)。
TNFRSF9蛋白與配體4-1BBL（TNFSF9）結(jié)合，激活下游的NF-κB信號(hào)通路，促進(jìn)T細(xì)胞的克隆增殖、存活和發(fā)育。TNFRSF9在免疫應(yīng)答中發(fā)揮關(guān)鍵作用，特別是在增強(qiáng)T細(xì)胞介導(dǎo)的免疫反應(yīng)和調(diào)節(jié)細(xì)胞毒性T細(xì)胞的活性方面。
TNFRSF9的表達(dá)還與多種疾病相關(guān)，包括自身免疫疾病和腫瘤等，是免疫治療的潛在靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFRSF9 at 2 μg/ml can bind TNFSF9（CSB-MP023997HU1）, the EC50 is 1.011-2.429 ng/mL.
TNFRSF9 Antibody (CSB-PA08109A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: HepG2 whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate
All lanes: TNFRSF9 antibody at 2.7µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 65 kDa
Immunofluorescent analysis of A549 cells using CSB-PA08109A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TNFRSF9 Antibodies
TNFRSF9 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011218 | TNFRSF9 Antibody | Human | WB, IF, ELISA |
| CSB-PA983768 | TNFRSF9 Antibody | Human | ELISA,IHC |
| CSB-PA718806 | TNFRSF9 Antibody | Human | IHC,ELISA |
| CSB-PA08109A0Rb | TNFRSF9 Antibody | Human | ELISA, WB, IF |
| CSB-PA08109B0Rb | TNFRSF9 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08109C0Rb | TNFRSF9 Antibody, FITC conjugated | Human | |
| CSB-PA08109D0Rb | TNFRSF9 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA023984A1HU | TNFRSF9/4-1BB?Recombinant Monoclonal Antibody | Human | ELISA |
TNFRSF9 Proteins
TNFRSF9 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023984MO1 CSB-EP023984MO1 CSB-BP023984MO1 CSB-MP023984MO1 CSB-EP023984MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 9 (Tnfrsf9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023984MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 9 (Tnfrsf9) | in vitro E.coli expression system |
TNFRSF9 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-AP001951HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 protein (TNFRSF9), partial | E.Coli |
| CSB-AP005131HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) | Mammalian cell |
| CSB-AP005141HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) | Mammalian cell |
| CSB-AP005151HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) | Mammalian cell |
| CSB-MP023984HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) | Mammalian cell |
TNFRSF9 ELISA Kit
TNFRSF9 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023984HU | Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9) ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
TNFRSF9 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023984MO | Mouse Tumor necrosis factor receptor superfamily member 9(TNFRSF9) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/ml |
