TNFRSF11B

TNFRSF11B，即腫瘤壞死因子受體超家族11B，別名OCIF、TR1、OPG。它是一種分泌型糖蛋白，主要在骨代謝中起調(diào)節(jié)作用，能夠抑制骨的破壞和吸收。TNFRSF11B基因位于染色體8q24，包含5個(gè)內(nèi)含子和5個(gè)外顯子。其分子前體由401個(gè)氨基酸組成，成熟分子由380個(gè)氨基酸組成，包含7個(gè)區(qū)段（D1~D7），其中D1~D4結(jié)構(gòu)域與配體RANKL結(jié)合，發(fā)揮抑制破骨細(xì)胞形成的作用。TNFRSF11B在多種腫瘤中高表達(dá)，與腫瘤的發(fā)生發(fā)展密切相關(guān)，可能通過(guò)與TRAIL競(jìng)爭(zhēng)性結(jié)合，抑制腫瘤細(xì)胞凋亡，促進(jìn)腫瘤細(xì)胞的增殖和轉(zhuǎn)移。在腫瘤治療中，TNFRSF11B可能成為新的生物標(biāo)志物和治療靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) (Active) (CSB-MP023969HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFSF11 (CSB-MP023986HU1(F2)) at 10 μg/ml can bind human TNFRSF11B, the EC₅₀ is 2.651-7.646 ng/ml.

TNFRSF11B Antibody (CSB-PA08229A0Rb)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA08229A0Rb at dilution of 1:100

TNFRSF11B Antibody

TNFRSF11B Protein

TNFRSF11B ELISA Kit

TNFRSF11B Antibodies

TNFRSF11B for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA119257	TNFRSF11B Antibody	Human,Mouse	ELISA,WB
CSB-PA003597	TNFRSF11B Antibody	Human,Mouse	WB, IHC, IF, ELISA
CSB-PA213664	TNFRSF11B Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA210767	TNFRSF11B Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA08229A0Rb	TNFRSF11B Antibody	Human	ELISA, IHC
CSB-PA08229B0Rb	TNFRSF11B Antibody, HRP conjugated	Human	ELISA
CSB-PA08229C0Rb	TNFRSF11B Antibody, FITC conjugated	Human
CSB-PA08229D0Rb	TNFRSF11B Antibody, Biotin conjugated	Human	ELISA

TNFRSF11B Proteins

TNFRSF11B Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP023969BO CSB-EP023969BO CSB-BP023969BO CSB-MP023969BO CSB-EP023969BO-B	Recombinant Bovine Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFRSF11B Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP023969RA CSB-EP023969RA CSB-BP023969RA CSB-MP023969RA CSB-EP023969RA-B	Recombinant Rat Tumor necrosis factor receptor superfamily member 11B (Tnfrsf11b)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFRSF11B Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP023969MO CSB-EP023969MO CSB-BP023969MO CSB-MP023969MO CSB-EP023969MO-B	Recombinant Mouse Tumor necrosis factor receptor superfamily member 11B (Tnfrsf11b)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFRSF11B Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP023969HU CSB-EP023969HU CSB-BP023969HU CSB-EP023969HU-B	Recombinant Human Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-AP002991HU	Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein (TNFRSF11B), partial (Active)	Yeast
CSB-AP003001HU	Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein (TNFRSF11B), partial (Active)	E.Coli
CSB-AP004951HU	Recombinant Human Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) (Active)	Mammalian cell
CSB-MP023969HU	Recombinant Human Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) (Active)	Mammalian cell