TMEM65
TMEM65，全稱為 transmembrane protein 65，是一種位于線粒體內(nèi)膜的蛋白質(zhì)。該蛋白在心臟和大腦中高表達(dá)，參與細(xì)胞內(nèi)鈣離子的調(diào)節(jié)，并與線粒體鈣超載相關(guān)疾病的發(fā)生發(fā)展密切相關(guān)。研究表明，TMEM65 蛋白能夠與線粒體鈉鈣交換器（NCLX）相互作用，調(diào)節(jié)鈣離子從線粒體中排出，維持細(xì)胞內(nèi)鈣離子穩(wěn)態(tài)。TMEM65 蛋白的缺失會(huì)導(dǎo)致線粒體鈣離子積累，進(jìn)而引發(fā)線粒體功能障礙和細(xì)胞凋亡。因此，TMEM65 蛋白被視為線粒體鈣離子失調(diào)相關(guān)疾病的重要治療靶點(diǎn)。目前，研究人員正在探索針對 TMEM65 蛋白的藥物，以治療心力衰竭、阿爾茨海默病等疾病。
熱銷產(chǎn)品
Recombinant Human Transmembrane protein 65 (TMEM65), partial (CSB-CF023869HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TMEM65 Antibody (CSB-PA023869LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: SY5Y whole cell lysate(20μg), Mouse Brain tissue lysate(20μg),Rat Brain tissue lysate(20μg)
All lanes: TMEM65 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 26 kDa
Observed band size: 20-25 kDa
Exposure time: 300s
TMEM65 Antibodies
TMEM65 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023869LA01HU | TMEM65 Antibody | Human, Mouse, Rat | ELISA, WB |
| CSB-PA023869LB01HU | TMEM65 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023869LC01HU | TMEM65 Antibody, FITC conjugated | Human | |
| CSB-PA023869LD01HU | TMEM65 Antibody, Biotin conjugated | Human | ELISA |
TMEM65 Proteins
TMEM65 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023869HU CSB-EP023869HU CSB-BP023869HU CSB-MP023869HU CSB-EP023869HU-B |
Recombinant Human Transmembrane protein 65 (TMEM65), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TMEM65 Proteins for Homo sapiens(Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-CF023869HU | Recombinant Human Transmembrane protein 65 (TMEM65), partial | in vitro E.coli expression system |
