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TMED4

TMED4,即跨膜p24運輸蛋白4。別名HNLF、ERS25、p24a3。TMED4在多種細胞過程中發揮作用,包括內質網應激反應、熱休克反應、細胞凋亡以及囊泡蛋白運輸,主要在早期分泌途徑中。
TMED4的作用機制涉及內質網應激(ERS)的調節,通過IRE1α-XBP1信號通路和NRF2相關的抗氧化反應,促進調節性T細胞(Treg)中活性氧(ROS)的穩態,維持Treg細胞Foxp3的表達及抑制功能。TMED4對于維持Treg細胞的穩定性和功能至關重要,其缺失會導致Treg細胞中Foxp3穩定性降低,影響Treg細胞的抑制功能,進而可能導致T細胞過度激活和炎癥反應加劇。TMED4還可能通過ER相關的降解(ERAD)系統抑制IRE1α的蛋白酶體降解。TMED4的功能異常與多種疾病相關,包括神經細胞脂褐素沉積癥8型。

熱銷產品

TMED4 Antibody (CSB-PA639635)

驗證數據

CSB-PA639635

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA639635(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA639635

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA639635(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA639635

Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-5: HepG2 cells, K562 cells, Hela cells, A549 cells, Mouse intestines tissue,Primary antibody: CSB-PA639635(TMED4 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute

TMED4 Antibodies

TMED4 for Homo sapiens (Human)

TMED4 Proteins

TMED4 Proteins for Homo sapiens (Human)