TLR3
Toll樣受體3（TLR3）也被稱為CD283，是人體先天免疫系統(tǒng)的重要成員。這類蛋白能夠特異性識(shí)別病毒入侵時(shí)釋放的雙鏈RNA成分，迅速啟動(dòng)干擾素等抗病毒因子的生成，幫助清除病原體。TLR3的功能異常與病毒性腦炎、慢性乙型肝炎等感染性疾病密切相關(guān)，其基因突變可能削弱機(jī)體對(duì)皰疹病毒、流感病毒的防御能力。在腫瘤領(lǐng)域，TLR3的激活被發(fā)現(xiàn)可誘導(dǎo)某些癌細(xì)胞的凋亡，黑色素瘤、乳腺癌等惡性腫瘤組織中常伴隨該受體表達(dá)量的顯著變化。目前全球已有十余款TLR3靶向藥物進(jìn)入臨床試驗(yàn)，例如美國某生物公司開發(fā)的候選藥物通過鼻腔給藥增強(qiáng)呼吸道抗病毒能力，另一款小分子激動(dòng)劑正在晚期實(shí)體瘤患者中評(píng)估療效。值得注意的是，過度激活TLR3可能誘發(fā)類風(fēng)濕性關(guān)節(jié)炎等自身免疫反應(yīng)，因此新型藥物的研發(fā)需精準(zhǔn)平衡免疫激活與抑制的窗口。
熱銷產(chǎn)品
TLR3 Antibody (CSB-PA023602LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA023602LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA023602LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA023602LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TLR3 Antibodies
TLR3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA191967 | TLR3 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA218546 | TLR3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA697913 | TLR3 Antibody | Human | ELISA,IHC |
| CSB-PA157170 | TLR3 Antibody | Human | ELISA,IHC |
| CSB-PA023602LA01HU | TLR3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA023602LB01HU | TLR3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023602LC01HU | TLR3 Antibody, FITC conjugated | Human | |
| CSB-PA023602LD01HU | TLR3 Antibody, Biotin conjugated | Human | ELISA |
TLR3 Proteins
TLR3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023602HU CSB-EP023602HU CSB-BP023602HU CSB-MP023602HU CSB-EP023602HU-B |
Recombinant Human Toll-like receptor 3 (TLR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023602BO CSB-EP023602BO CSB-BP023602BO CSB-MP023602BO CSB-EP023602BO-B |
Recombinant Bovine Toll-like receptor 3 (TLR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023602MO CSB-EP023602MO CSB-BP023602MO CSB-MP023602MO CSB-EP023602MO-B |
Recombinant Mouse Toll-like receptor 3 (Tlr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR3 Proteins for Boselaphus tragocamelus (Nilgai)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023602BUN CSB-EP023602BUN CSB-BP023602BUN CSB-MP023602BUN CSB-EP023602BUN-B |
Recombinant Boselaphus tragocamelus Toll-like receptor 3 (TLR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
