TGFA

TGFA全稱為轉(zhuǎn)化生長因子α，是一種表皮生長因子家族成員，常被稱為TGF-alpha或TDGF。該蛋白通過與細胞表面的表皮生長因子受體結(jié)合，觸發(fā)細胞增殖、分化及遷移，廣泛參與胚胎發(fā)育、組織修復等生理過程。TGF-α的異常表達與多種癌癥密切相關，例如乳腺癌、結(jié)直腸癌及肺癌中常見其水平升高，可能通過過度激活細胞生長信號導致腫瘤惡化。此外，該蛋白在炎癥性腸病、銀屑病等慢性炎癥疾病中也顯示出促炎作用。
近年來，針對TGF-α相關通路的藥物研發(fā)取得進展，例如EGFR抑制劑厄洛替尼、吉非替尼已用于非小細胞肺癌治療，單抗藥物西妥昔單抗則在結(jié)直腸癌中展現(xiàn)療效。部分研究正探索聯(lián)合用藥策略，例如將EGFR靶向藥與免疫檢查點抑制劑結(jié)合，以克服耐藥性問題。與此同時，科學家也在開發(fā)特異性更高的雙特異性抗體，試圖精準阻斷TGF-α與其受體的相互作用，相關臨床試驗已進入早期階段。

熱銷產(chǎn)品

TGFA Antibody (CSB-PA07294A0Rb)

驗證數(shù)據(jù)

Western blot
All lanes: TGFA antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 18, 17 kDa
Observed band size: 30, 35 kDa

Immunofluorescent analysis of Hela cells using CSB-PA07294A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA07294A0Rb at dilution of 1:100

Human transforming growth factor α,TGF-α ELISA Kit (CSB-E04724h)

驗證數(shù)據(jù)

貨號：CSB-E04724h

規(guī)格：96T/48T

靈敏度：5.48 pg/ml

檢測范圍：5.48 pg/ml-4000 pg/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TGFA Antibody

TGFA Protein

TGFA ELISA Kit

TGFA Antibodies

TGFA for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA07294A0Rb	TGFA Antibody	Human	ELISA, WB, IHC, IF
CSB-PA799735	TGFA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA004275	TGFA Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA582653	TGFA Antibody	Human,Mouse,Rat	ELISA,IHC

TGFA Proteins

TGFA Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023445SH	Recombinant Sheep Protransforming growth factor alpha (TGFA), partial	Yeast
CSB-EP023445SH	Recombinant Sheep Protransforming growth factor alpha (TGFA), partial	E.coli
CSB-BP023445SH CSB-MP023445SH CSB-EP023445SH-B	Recombinant Sheep Protransforming growth factor alpha (TGFA), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TGFA Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023445RB CSB-EP023445RB CSB-BP023445RB CSB-MP023445RB CSB-EP023445RB-B	Recombinant Rabbit Transforming growth factor alpha (TGFA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TGFA Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023445MO CSB-EP023445MO CSB-BP023445MO CSB-MP023445MO CSB-EP023445MO-B	Recombinant Mouse Protransforming growth factor alpha (Tgfa), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TGFA Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023445MOW1 CSB-EP023445MOW1 CSB-BP023445MOW1 CSB-MP023445MOW1 CSB-EP023445MOW1-B	Recombinant Macaca mulatta (Rhesus macaque) Protransforming growth factor alpha (TGFA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023445MOW	Recombinant Macaca mulatta (Rhesus macaque) Protransforming growth factor alpha (TGFA)	in vitro E.coli expression system

TGFA Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023445HU1 CSB-EP023445HU1 CSB-BP023445HU1 CSB-MP023445HU1 CSB-EP023445HU1-B	Recombinant Human Protransforming growth factor alpha (TGFA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023445HU	Recombinant Human Protransforming growth factor alpha (TGFA)	in vitro E.coli expression system
CSB-EP072944h CSB-EP072944h-B	Recombinant Human Protransforming growth factor alpha (TGFA)	E.coli In Vivo Biotinylation in E.coli

TGFA Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP360628RA CSB-BP360628RA CSB-MP360628RA CSB-EP360628RA-B	Recombinant Rat Protransforming growth factor alpha (Tgfa), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli