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TEAD1

TEAD1,即睪丸特異性轉錄增強子1,別名TEF-1、TEF-2、TEAD4、RTEF-1等。它是一種轉錄因子,屬于TEA/ATTS家族成員,由人體細胞自身的基因編碼。TEAD1在多種組織中都有表達,尤其在心臟、肌肉和生殖系統等組織中表達較高。TEAD1的作用機制主要是通過與DNA上的特定序列結合,調控下游基因的轉錄。TEAD1可以與多種轉錄共激活因子如YAP1相互作用,形成復合體,進而激活或抑制特定基因的表達。TEAD1在生物學上的意義非常廣泛,它參與了多種細胞生命活動的調控,包括細胞增殖、分化、遷移和凋亡等。TEAD1通過參與調控細胞周期相關基因的表達,影響細胞的增殖和周期進程。此外,TEAD1還參與了心臟和血管的發育、肌肉的再生以及生殖細胞的分化等過程。在腫瘤細胞中,TEAD1的異常表達與腫瘤的發生發展密切相關,其功能異常可能導致細胞惡性增殖和轉移。因此,TEAD1是細胞生物學和疾病研究中的一個重要轉錄因子,也是藥物開發和疾病治療中的潛在靶點。

熱銷產品

Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1), partial (CSB-EP023363HU1)

驗證數據

CSB-EP023363HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TEAD1 Antibody (CSB-PA023363DSR2HU)

驗證數據

CSB-PA023363DSR2HU

Western Blot
Positive WB detected in: HepG2 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate
All lanes: TEAD1 antibody at 3.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa

CSB-PA023363DSR2HU

IHC image of CSB-PA023363DSR2HU diluted at 1:441 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA023363DSR2HU

Immunofluorescence staining of A549 cells with CSB-PA023363DSR2HU at 1:147, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

TEAD1 Antibodies

TEAD1 for Homo sapiens (Human)

TEAD1 Proteins

TEAD1 Proteins for Mus musculus (Mouse)

TEAD1 Proteins for Homo sapiens (Human)



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