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STK3

Serine/threonine-protein kinase 3 is a protein in humans that is encoded by STK3 gene. Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

STK3 Antibodies

STK3 for Homo sapiens (Human)

STK3 Proteins

STK3 Proteins for Rattus norvegicus (Rat)

STK3 Proteins for Homo sapiens (Human)

STK3 Proteins for Xenopus laevis (African clawed frog)

STK3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

STK3 Proteins for Mus musculus (Mouse)



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