STAMBP
STAMBP，全稱為STAM結(jié)合蛋白，是一種去泛素化酶，在細(xì)胞表面受體運(yùn)輸中發(fā)揮關(guān)鍵作用。它具有多個(gè)別名，包括AMSH、MGC126516和MGC126518。STAMBP通過催化K63連接型泛素鏈的斷裂，參與ESCRT介導(dǎo)的細(xì)胞表面受體回收過程。研究發(fā)現(xiàn)，STAMBP的MIT結(jié)構(gòu)域?qū)ζ淙シ核鼗富钚跃哂凶砸种乒δ埽@一發(fā)現(xiàn)為理解STAMBP在膜受體轉(zhuǎn)運(yùn)過程中的功能提供了新的視角。此外，STAMBP還與多種疾病密切相關(guān)，如三陰性乳腺癌（TNBC），其在腫瘤發(fā)生發(fā)展中扮演重要角色。目前，針對(duì)STAMBP的藥物研發(fā)取得了一定進(jìn)展，例如，STAMBP抑制劑BC-1471已被發(fā)現(xiàn)可以抑制MDA-MB-231細(xì)胞的生長，盡管效果尚不顯著，但為開發(fā)更有效的STAMBP抑制劑提供了重要線索。未來，深入探究STAMBP的功能及其在疾病中的作用機(jī)制，將有助于開發(fā)更精準(zhǔn)的治療策略。
熱銷產(chǎn)品
STAMBP Antibody (CSB-PA022794HA01HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: STAMBP antibody at 12µg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49, 40 kDa
Observed band size: 49 kDa
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA022794HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA022794HA01HU at dilution of 1:100
STAMBP Antibodies
STAMBP for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA022794GA01HU | STAMBP Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA022794HA01HU | STAMBP Antibody | Human | ELISA, WB, IHC |
| CSB-PA477062 | STAMBP Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA078977 | STAMBP Antibody | Human,Mouse,Rat | ELISA,IHC |
STAMBP Proteins
STAMBP Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022794HU CSB-EP022794HU CSB-BP022794HU CSB-MP022794HU CSB-EP022794HU-B |
Recombinant Human STAM-binding protein (STAMBP) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAMBP Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP731019XBE CSB-EP731019XBE CSB-BP731019XBE CSB-MP731019XBE CSB-EP731019XBE-B |
Recombinant Xenopus laevis STAM-binding protein-like (stambp) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAMBP Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP848124RA CSB-EP848124RA CSB-BP848124RA CSB-MP848124RA CSB-EP848124RA-B |
Recombinant Rat STAM-binding protein (Stambp) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAMBP Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP887415MO CSB-EP887415MO CSB-BP887415MO CSB-MP887415MO CSB-EP887415MO-B |
Recombinant Mouse STAM-binding protein (Stambp) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
