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SOST

SOST,即硬化蛋白,別名Sclerostin、VBCH。它是一種由SOST基因編碼的分泌型糖蛋白,屬于Cerberus/Dan家族的骨形態發生蛋白(BMP)拮抗劑。SOST在骨骼系統中由骨細胞產生,具有抗骨形成作用。其作用機制主要是通過與LRP5/6受體結合,抑制Wnt信號通路,從而對骨形成產生抑制作用。SOST對維持骨穩態、骨密度維持和骨折愈合等方面至關重要,其異常表達與多種骨骼疾病相關,包括骨質疏松癥、骨折愈合障礙以及遺傳性骨疾病如硬化性骨病和van Buchem病等,是治療代謝性骨病和促進骨折修復的潛在治療靶點。

熱銷產品

SOST Recombinant Monoclonal Antibody (CSB-RA858415MA1HU)

驗證數據

CSB-RA858415MA1HU

IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA858415MA1HU

IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Human Sclerostin(SOST) ELISA Kit (CSB-E13146h)

驗證數據

CSB-E13146h 標準曲線

貨號:CSB-E13146h

規格:96T/48T

靈敏度:7.8 pg/mL

檢測范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SOST Antibodies

SOST for Homo sapiens (Human)

SOST Proteins

SOST Proteins for Mus musculus (Mouse)

SOST Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

SOST Proteins for Homo sapiens (Human)

SOST Proteins for Rattus norvegicus (Rat)

SOST Proteins for Bos taurus (Bovine)

SOST ELISA Kit

SOST ELISA Kit for Homo sapiens (Human)

SOST ELISA Kit for Rattus norvegicus (Rat)



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