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SMPD3

SMPD3,全稱為鞘磷脂磷酸二酯酶3,是一種在細胞膜上發揮重要作用的酶。它有多種別名,如中性鞘磷脂酶II。SMPD3的主要功能是參與鞘磷脂的代謝,鞘磷脂是一種重要的脂質分子,與細胞膜的穩定性和信號傳導有關。在肝臟疾病中,如代謝功能障礙相關脂肪性肝炎(MASH),SMPD3的表達和活性異常可能導致脂質代謝紊亂,進而引發炎癥和纖維化。近年來,研究人員發現靶向SMPD3可能成為治療MASH的新策略,目前已有針對SMPD3的雙靶點藥物進入研發階段,顯示出良好的治療前景。

熱銷產品

Recombinant Human Sphingomyelin phosphodiesterase 3 (SMPD3), partial (CSB-EP878920HU1)

驗證數據

CSB-EP878920HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SMPD3 Antibody (CSB-PA878920LA01HU)

驗證數據

CSB-PA878920LA01HU

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA878920LA01HU at dilution of 1:100

CSB-PA878920LA01HU

Immunoprecipitating SMPD3 in mouse brain whole cell lysate
Lane 1: Rabbit control IgG (1μg) instead of CSB-PA878920LA01HU in mouse brain whole cell lysate.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA878920LA01HU (6μg) + Mouse brain whole cell lysate (500μg)
Lane 3: Mouse brain whole cell lysate (10μg)

SMPD3 Antibodies

SMPD3 for Homo sapiens (Human)

SMPD3 Proteins

SMPD3 Proteins for Homo sapiens (Human)