SLFN11
SLFN11，全稱為Schlafen 11，是一種干擾素誘導(dǎo)的抗病毒限制因子，具有tRNA內(nèi)切核糖核酸酶和DNA結(jié)合功能。它在復(fù)制應(yīng)激期間被招募到停滯的復(fù)制叉，并可能不可逆地觸發(fā)復(fù)制阻塞和細胞死亡。SLFN11的基因參與細胞在化療后的細胞命運決定，并編碼N-末端核糖核酸酶(RNase)結(jié)構(gòu)域和C-末端解旋酶/ATP酶結(jié)構(gòu)域。這些結(jié)構(gòu)域?qū)煼磻?yīng)的貢獻仍有爭議。SLFN11在循環(huán)腫瘤細胞中的動態(tài)表達可作為小細胞肺癌的液體生物標(biāo)志物，其表達水平在接受鉑類治療的患者中較低，并且與臨床反應(yīng)相關(guān)。在預(yù)測對包括鉑類藥物和PARP抑制劑在內(nèi)的多種藥物引起的DNA損傷治療的反應(yīng)中，SLFN11是一個有前景的生物標(biāo)志物。
熱銷產(chǎn)品
Recombinant Human Schlafen family member 11 (SLFN11), partial (CSB-EP021760HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SLFN11 Antibody (CSB-PA021760LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Mouse skeletal muscle tissue
All lanes: SLFN11 antibody at 2.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 103 kDa
Observed band size: 103 kDa
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA021760LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA021760LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SLFN11 Antibodies
SLFN11 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021760LA01HU | SLFN11 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA021760LB01HU | SLFN11 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021760LC01HU | SLFN11 Antibody, FITC conjugated | Human | |
| CSB-PA021760LD01HU | SLFN11 Antibody, Biotin conjugated | Human | ELISA |
SLFN11 Proteins
SLFN11 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021760HU CSB-EP021760HU CSB-BP021760HU CSB-MP021760HU CSB-EP021760HU-B |
Recombinant Human Schlafen family member 11 (SLFN11), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP021760HU1 | Recombinant Human Schlafen family member 11 (SLFN11), partial | E.coli |
| CSB-EP021760HU(A4) | Recombinant Human Schlafen family member 11 (SLFN11) | E.coli |
| CSB-BP021760HU(A4) | Recombinant Human Schlafen family member 11 (SLFN11) | Baculovirus |
