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SLC22A12

SLC22A12,即溶質(zhì)載體家族22成員12,別名尿酸鹽轉(zhuǎn)運蛋白1(URAT1)、新型腎臟轉(zhuǎn)運蛋白(NKT)。它是一種主要在腎臟近端小管上皮細胞的頂端刷緣膜上表達的跨膜蛋白,負責尿酸鹽的重吸收過程。SLC22A12的作用機制是通過利用管腔兩側(cè)的濃度梯度和化學梯度差,將尿酸鹽從近端腎小管腔內(nèi)轉(zhuǎn)運到腎小管上皮細胞,這是尿酸鹽重吸收的第一步。SLC22A12在生物學上的意義主要體現(xiàn)在其對尿酸鹽平衡的調(diào)控作用。它參與調(diào)節(jié)血尿酸水平,影響尿酸的排泄和重吸收。SLC22A12的功能缺失突變會導致尿酸鹽重吸收功能障礙,可能引起1型腎低尿酸血癥。此外,SLC22A12中的單核苷酸多態(tài)性(SNP)與代謝綜合征的發(fā)病機制有關,包括肥胖、低高密度脂蛋白膽固醇、腰圍增加等。因此,SLC22A12是研究和治療與尿酸鹽代謝相關的疾病,如痛風和高尿酸血癥的潛在靶點。

熱銷產(chǎn)品

SLC22A12 Antibody (CSB-PA041473)

驗證數(shù)據(jù)

CSB-PA041473

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA041473(SLC22A12 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA041473

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA041473(SLC22A12 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA041473

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, 293T cells, Primary antibody: CSB-PA041473(SLC22A12 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds

SLC22A12 Antibodies

SLC22A12 for Homo sapiens (Human)

SLC22A12 Proteins

SLC22A12 Proteins for Homo sapiens (Human)