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SLAMF6

SLAMF6,全稱為信號(hào)淋巴細(xì)胞激活分子6(SLAM family member 6),也被稱為NTB-A或CD352,屬于SLAM家族成員。該蛋白是一種單程I型膜蛋白,主要由細(xì)胞外結(jié)構(gòu)域、跨膜區(qū)和胞質(zhì)區(qū)組成。SLAMF6 蛋白廣泛分布于免疫細(xì)胞表面,如T細(xì)胞、B細(xì)胞、NK細(xì)胞和樹突狀細(xì)胞等,并在免疫細(xì)胞的活化、分化和粘附中發(fā)揮重要作用。SLAMF6 蛋白通過與同源或異源分子相互作用,調(diào)節(jié)免疫細(xì)胞的激活和分化,影響先天性和適應(yīng)性免疫反應(yīng)。此外,SLAMF6 蛋白還參與多種免疫調(diào)節(jié)過程,如細(xì)胞因子分泌、細(xì)胞增殖和細(xì)胞凋亡等。SLAMF6 蛋白與多種疾病相關(guān),包括癌癥、自身免疫性疾病和感染性疾病等。目前,針對(duì)SLAMF6 蛋白的藥物研發(fā)尚處于起步階段,但已有研究表明,靶向SLAMF6 蛋白的抗體和藥物可能成為治療癌癥和自身免疫性疾病的新策略。

熱銷產(chǎn)品

Recombinant Human SLAM family member 6 (SLAMF6), partial (CSB-MP021368HU)

驗(yàn)證數(shù)據(jù)

CSB-MP021368HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP021368HU

The purity of SLAMF6 was greater than 90% as determined by SEC-HPLC

SLAMF6 Antibody (CSB-PA021368LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA021368LA01HU

Western Blot
Positive WB detected in: Hela whole cell lysate, HL60 whole cell lysate, 293T whole cell lysate, A549 whole cell lysate, Mouse kidney tissue
All lanes: SLAMF6 antibody at 5.1μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38, 25 kDa
Observed band size: 60 kDa

CSB-PA021368LA01HU

IHC image of CSB-PA021368LA01HU diluted at 1:200 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA021368LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA021368LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SLAMF6 Antibodies

SLAMF6 for Homo sapiens (Human)

SLAMF6 Proteins

SLAMF6 Proteins for Homo sapiens (Human)