SIRT3

SIRT3，作為線粒體中的關鍵去乙酰化修飾酶，其結構包括一個催化區以及調節酶活性的N端和C端結構。它在細胞應激時轉移到線粒體內并成熟，從而發揮其去乙酰化功能。SIRT3主要通過調節線粒體結構和功能，如激活長鏈脂酰輔酶A脫氫酶，在脂肪代謝中發揮重要作用。在信號通路方面，SIRT3通過調控GSK-3β/β-catenin信號通路來抑制NLRP3炎性小體的表達，從而保護骨骼成骨。同時，在腎臟疾病中，SIRT3通過去乙酰化作用抑制腎纖維化，并調控能量代謝穩態。此外，SIRT3還參與心臟氧化應激、缺血再灌注損傷等生理和病理過程。

熱銷產品

Recombinant Rat NAD-dependent protein deacetylase (Sirt3)

驗證數據

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SIRT3 Antibody

SIRT3 Protein

SIRT3 ELISA Kit

SIRT3 Antibodies

SIRT3 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA882102ESR1HU	SIRT3 Antibody	Human	ELISA, WB, IHC
CSB-PA882102ESR2HU	SIRT3 Antibody	Human	ELISA, WB, IHC
CSB-PA229200	SIRT3 Antibody	Human	ELISA,WB
CSB-PA008365	SIRT3 Antibody	Human	WB, ELISA
CSB-PA100396	SIRT3 Antibody	Human,Mouse	ELISA,IHC
CSB-PA937428	SIRT3 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA882102LA01HU	SIRT3 Antibody	Human	ELISA, IF
CSB-PA882102LB01HU	SIRT3 Antibody, HRP conjugated	Human	ELISA
CSB-PA882102LD01HU	SIRT3 Antibody, Biotin conjugated	Human	ELISA

SIRT3 Proteins

SIRT3 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP882102HU CSB-EP882102HU CSB-BP882102HU CSB-MP882102HU CSB-EP882102HU-B	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP882102HU1	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3), partial	E.coli
CSB-EP882102HU1(M)	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) (R235A,E246A), partial	E.coli
CSB-EP882102HU2(M)	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) (R235A,E246A), partial	E.coli