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SIRT1

SIRT1,即細胞衰老相關蛋白1,別名Sirtuin 1、NAD依賴性去乙酰化酶1等。SIRT1是一種由SIRT1基因編碼的蛋白質,屬于Sirtuin家族成員之一,主要在細胞核中發揮作用。它是一種依賴于煙酰胺腺嘌呤二核苷酸(NAD+)的去乙酰化酶,通過去除蛋白質上的乙酰基團來調控多種細胞過程,包括細胞代謝、應激反應、細胞周期和衰老。SIRT1的作用機制涉及到對多種底物蛋白的去乙酰化修飾,這些底物包括但不限于組蛋白、轉錄因子、DNA修復蛋白和信號傳導分子。SIRT1在生物學上的意義非常廣泛,它參與調節多種細胞生理過程和代謝途徑。SIRT1通過去乙酰化作用參與調控細胞的能量代謝,促進細胞對應激的適應性,保護細胞免受氧化損傷。此外,SIRT1還參與調節細胞周期和細胞衰老過程,影響細胞的增殖和分化。SIRT1的功能異常與多種疾病的發生發展有關,包括代謝性疾病、神經退行性疾病、心血管疾病和癌癥。因此,SIRT1是藥物開發和疾病治療中的一個潛在靶點,其激動劑和抑制劑的研究正在積極進行中。

熱銷產品

Recombinant Human NAD-dependent protein deacetylase sirtuin-1 (SIRT1) (CSB-EP822202HU)

驗證數據

CSB-EP822202HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SIRT1 Recombinant Monoclonal Antibody (CSB-RA556800A0HU)

驗證數據

CSB-RA556800A0HU

IHC image of CSB-RA556800A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA556800A0HU

Immunofluorescence staining of Hela Cells with CSB-RA556800A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

SIRT1 Antibodies

SIRT1 for Homo sapiens (Human)

SIRT1 Proteins

SIRT1 Proteins for Homo sapiens (Human)

SIRT1 Proteins for Mus musculus (Mouse)

SIRT1 ELISA Kit

SIRT1 ELISA Kit for Mus musculus (Mouse)

SIRT1 ELISA Kit for Homo sapiens (Human)



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