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SIGLEC7

SIGLEC7,全名為唾液酸結合免疫球蛋白樣凝集素7,常見別名為Siglec-7、Sialic acid-binding Ig-like lectin 7、D-siglec、CD328。該蛋白主要在自然殺傷細胞和髓系細胞表面表達,通過結合唾液酸修飾的配體傳遞抑制性信號,負調控免疫細胞活化,維持免疫穩態。SIGLEC7在疾病中與某些癌癥(如黑色素瘤、白血病)進展相關,腫瘤微環境可能上調其表達以抑制抗腫瘤免疫。此外,SIGLEC7多態性與過敏性疾病(如哮喘)的易感性有關。目前,針對SIGLEC7的藥物研發主要集中在免疫檢查點抑制劑和靶向治療領域,旨在通過阻斷其抑制通路以增強抗腫瘤免疫,或利用其抑制特性治療自身免疫性疾病。

熱銷產品

SIGLEC7 Antibody (CSB-PA896485LA01HU)

驗證數據

CSB-PA896485LA01HU

Western Blot
Positive WB detected in: Mouse heart tissue, Mouse kidney tissue
All lanes: SIGLEC7 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 42, 17 kDa
Observed band size: 52 kDa

CSB-PA896485LA01HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA896485LA01HU at dilution of 1:100

CSB-PA896485LA01HU

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA896485LA01HU at dilution of 1:100

CSB-PA896485LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA896485LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

SIGLEC7 Antibodies

SIGLEC7 for Homo sapiens (Human)

SIGLEC7 Proteins

SIGLEC7 Proteins for Homo sapiens (Human)