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SHC1

SHC-transforming protein 1 is a protein in humans that is encoded by SHC1 gene. Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.

SHC1 Antibodies

SHC1 for Homo sapiens (Human)

SHC1 Proteins

SHC1 Proteins for Mus musculus (Mouse)

SHC1 Proteins for Homo sapiens (Human)

SHC1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

SHC1 Proteins for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)

SHC1 Proteins for Bos taurus (Bovine)

SHC1 Proteins for Rattus norvegicus (Rat)

SHC1 Proteins for Pongo abelii (Sumatran orangutan)

SHC1 Proteins for Xenopus laevis (African clawed frog)



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