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SH3KBP1

SH3 domain-containing kinase-binding protein 1 is a protein in humans that is encoded by SH3KBP1 gene. Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP.

SH3KBP1 Antibodies

SH3KBP1 for Homo sapiens (Human)

SH3KBP1 Proteins

SH3KBP1 Proteins for Mus musculus (Mouse)

SH3KBP1 Proteins for Homo sapiens (Human)

SH3KBP1 Proteins for Rattus norvegicus (Rat)



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