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ROBO4

ROBO4,全稱為Roundabout homolog 4,別名包括MRB、AOVD3和ECSM4。該蛋白主要表達于內皮細胞,參與血管生成和內皮屏障的建立,并位于細胞外外體泡中。ROBO4與主動脈瓣疾病3相關,其突變可能導致主動脈瓣畸形、狹窄和升主動脈瘤等病癥。此外,ROBO4還參與調控心臟系統靜脈回流和心包膜的發育,其缺失會導致小鼠發育過程中的腎臟缺失和輸尿管發育不全。ROBO4蛋白通過與SLIT2蛋白結合,發揮抑制細胞間粘附介導活性的作用,從而穩定血管通透性和完整性。目前,針對ROBO4蛋白的藥物研發尚處于探索階段,但其在心血管疾病和腎臟疾病治療方面具有潛在的應用價值。

熱銷產品

Recombinant Human Roundabout homolog 4 (ROBO4),?partial (CSB-EP845177HU1d7)

驗證數據

CSB-EP845177HU1d7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ROBO4 Antibody (CSB-PA903544)

驗證數據

CSB-PA903544

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA903544(ROBO4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA903544

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA903544(ROBO4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Human Roundabout homolog 4(ROBO4) ELISA kit (CSB-EL020057HU)

驗證數據

CSB-EL020057HU 標準曲線

貨號:CSB-EL020057HU

規格:96T/48T

靈敏度:15.6 pg/mL

檢測范圍:62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ROBO4 Antibodies

ROBO4 for Homo sapiens (Human)

ROBO4 Proteins

ROBO4 Proteins for Homo sapiens (Human)

ROBO4 ELISA Kit

ROBO4 ELISA Kit for Homo sapiens (Human)