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RNF213

RNF213,全稱為環(huán)指蛋白213(Ring finger protein 213),是一種與多種血管相關(guān)疾病密切相關(guān)的蛋白質(zhì)。該蛋白在東亞人群中是煙霧病的主要易感基因,煙霧病是一種罕見的腦血管疾病,其特征為雙側(cè)頸內(nèi)動(dòng)脈末端及其主要分支逐漸閉塞,同時(shí)在顱底形成異常血管網(wǎng)絡(luò)。RNF213蛋白還與顱內(nèi)動(dòng)脈閉塞或狹窄、缺血性卒中、顱內(nèi)動(dòng)脈瘤、腦動(dòng)靜脈畸形等多種血管相關(guān)疾病有關(guān)。
RNF213蛋白具有廣泛的抗菌和抗病毒活性,可以通過泛素化脂多糖(LPS)或與ISGylated的病毒蛋白結(jié)合來對(duì)抗多種病原體。此外,RNF213蛋白還參與調(diào)節(jié)血管生成和血腦屏障的完整性。研究表明,RNF213蛋白的變異會(huì)導(dǎo)致腦血管異常,并導(dǎo)致煙霧病的發(fā)生。
目前,針對(duì)RNF213蛋白相關(guān)疾病的藥物研發(fā)尚處于早期階段。一些研究表明,抗血小板藥物可能有助于提高煙霧病患者的生存率和認(rèn)知功能。此外,煙霧病的搭橋手術(shù)也是一種有效的治療方法,可以預(yù)防中風(fēng)的發(fā)生。

熱銷產(chǎn)品

RNF213 Antibody (CSB-PA717453LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA717453LA01HU

IHC image of CSB-PA717453LA01HU diluted at 1:800 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA717453LA01HU

IHC image of CSB-PA717453LA01HU diluted at 1:800 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA717453LA01HU

Immunofluorescence staining of A549 cells with CSB-PA717453LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RNF213 Antibodies

RNF213 for Homo sapiens (Human)

RNF213 Proteins

RNF213 Proteins for Homo sapiens (Human)