RNASEH1（Ribonuclease H1）是核糖核酸內(nèi)切酶H1內(nèi)切酶。RNASEH1的主要功能是在DNA修復過程中起作用，特別是在RNA-DNA雜交物的剪切中。它有助于維持基因組穩(wěn)定性，通過消除RNA與DNA的雜交，防止不必要的雜交結(jié)構(gòu)的累積，并保持細胞的正常功能。研究表明，RNASEH1的突變或缺陷與一種罕見的遺傳性神經(jīng)系統(tǒng)退行性疾病——Aicardi-Goutières綜合征（AGS）相關(guān)。AGS通常伴隨著神經(jīng)系統(tǒng)發(fā)育異常和免疫系統(tǒng)異常，而RNASEH1的異?？赡芘c此類癥狀的出現(xiàn)有關(guān)。此外，RNASEH1在細胞生物學研究和RNA-DNA雜交相關(guān)領(lǐng)域也具有重要的應用潛力。對RNASEH1的深入研究不僅有助于理解細胞的核酸代謝和基因組穩(wěn)定性的維持，還可能為治療相關(guān)疾病提供新的治療方法或干預手段。

熱銷產(chǎn)品

Recombinant Human Ribonuclease H1 (RNASEH1)

驗證數(shù)據(jù)

SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS/MS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP019801HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RNASEH1.

LC-MS/MS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP019801HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RNASEH1.