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RBMS1

RBMS1,即RNA結合基序單鏈相互作用蛋白1,別名YC1、MSSP、SCR2、HCC-4、MSSP-1、MSSP-2、MSSP-3、C2orf12等。它是一種在人體中由RBMS1基因編碼的蛋白質,屬于RNA結合蛋白家族成員之一。RBMS1的作用機制涉及結合單鏈DNA/RNA,具有兩個核糖核蛋白共有序列(RNP-CS),含有保守基序RNP1和RNP2,這些基序最初在RNA結合蛋白中描述,并且對DNA結合是必需的。RBMS1參與多種生物學過程,包括DNA復制、基因轉錄、細胞周期進程和細胞凋亡 。RBMS1在生物學上的意義非常廣泛,它不僅參與了基因表達的調控,還與腫瘤免疫逃逸、細胞轉移和腫瘤抑制過程相關。例如,在三陰性乳腺癌中,RBMS1的下調能夠阻斷PD-L1免疫檢查點,促進抗腫瘤免疫 。在非小細胞肺癌中,RBMS1與m6A閱讀器YTHDF1相互作用,促進S100P的翻譯,加速癌細胞的轉移 。此外,RBMS1還通過調節SLC7A11的翻譯控制調節肺癌鐵死亡 。這些研究表明,RBMS1在腫瘤發展和轉移中發揮著重要作用,是腫瘤治療中的潛在靶點。

熱銷產品

RBMS1 Antibody (CSB-PA019440LA01HU)

驗證數據

CSB-PA019440LA01HU

Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate
All lanes: RBMS1 antibody at 3.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 5 kDa
Observed band size: 45 kDa

CSB-PA019440LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA019440LA01HU at 1:120, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RBMS1 Antibodies

RBMS1 for Homo sapiens (Human)

RBMS1 Proteins

RBMS1 Proteins for Homo sapiens (Human)