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RAF1

RAF1,即絲裂原活化蛋白激酶激酶1,別名CRAF、Raf-1、Raf激酶等。它是一種由RAF1基因編碼的蛋白激酶,屬于RAF家族成員,在多種細胞類型中表達。RAF1的作用機制涉及作為絲裂原活化蛋白激酶(MAPK)信號通路中的一個關鍵調節因子,通過磷酸化并激活下游的MEK1/2,進而激活ERK1/2,調控細胞增殖、分化、遷移和存活。RAF1參與了多種細胞生命活動的調控,包括細胞周期控制、細胞應激反應、細胞凋亡等。RAF1的功能異常與多種疾病有關,尤其是與癌癥的發生發展密切相關。RAF1的突變或異常激活可能導致腫瘤細胞的無限制增殖和抗藥性,使其成為癌癥治療中的一個潛在靶點。

熱銷產品

Recombinant Human RAF proto-oncogene serine/threonine-protein kinase (RAF1) (CSB-EP019284HUc7)

驗證數據

CSB-EP019284HUc7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Phospho-RAF1 (S621) Recombinant Monoclonal Antibody (CSB-RA019284A621phHU)

驗證數據

CSB-RA019284A621phHU

Western Blot
Positive WB detected in Hela whole cell lysate(treated with Calyculin A or EGF)
All lanes Phospho-RAF1 antibody at 1.525μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 73 KDa
Observed band size: 73 KDa

CSB-RA019284A621phHU

Immunofluorescence staining of HepG2 cells(treated with 50mM Calyculin A for 30min) with CSB-RA019284A621phHU at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

RAF1 Antibodies

RAF1 for Homo sapiens (Human)

RAF1 for Rattus norvegicus (Rat)

RAF1 Proteins

RAF1 Proteins for Rattus norvegicus (Rat)

RAF1 Proteins for Homo sapiens (Human)

RAF1 Proteins for Gallus gallus (Chicken)

RAF1 Proteins for Bos taurus (Bovine)

RAF1 Proteins for Xenopus laevis (African clawed frog)

RAF1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

RAF1 Proteins for Pongo abelii (Sumatran orangutan)

RAF1 Proteins for Mus musculus (Mouse)



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