PTEN
PTEN，全稱(chēng)為磷酸酯酶與張力蛋白同源物，是一種重要的抑癌蛋白，在多種癌癥的發(fā)生發(fā)展中發(fā)揮重要作用。PTEN蛋白常見(jiàn)別名包括BZS、DEC、CWS1、GLM2、MHAM、TEP1、MMAC1等。PTEN蛋白通過(guò)其脂質(zhì)磷酸酶活性，負(fù)向調(diào)控細(xì)胞內(nèi)磷脂酰肌醇-3,4,5-三磷酸的水平，從而抑制細(xì)胞增殖、粘附、遷移、血管生成等過(guò)程，并促進(jìn)細(xì)胞凋亡、分化、衰老等。PTEN蛋白與多種信號(hào)通路相關(guān)，如PI3K/Akt通路、FAK通路以及MAPK通路等。
PTEN蛋白的失活或功能缺陷與多種癌癥的發(fā)生發(fā)展密切相關(guān)，包括肺癌、前列腺癌、乳腺癌、甲狀腺癌等。近年來(lái)，PTEN蛋白在肝癌、非小細(xì)胞肺癌等疾病中的研究也成為熱點(diǎn)。針對(duì)PTEN蛋白的藥物研發(fā)也在不斷推進(jìn)，例如阿斯利康公司研發(fā)的Truqap（通用名：capivasertib）是一種AKT抑制劑，已在全球多個(gè)國(guó)家獲批用于治療HR陽(yáng)性局部晚期或轉(zhuǎn)移性乳腺癌患者。此外，重組腺病毒介導(dǎo)的PTEN療法也在前列腺癌的治療中展現(xiàn)出良好的前景。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western Blot analysis of Hela cells using PTEN Polyclonal Antibody
Western Blot analysis of L929 COLO 293T HELA MOUSE-brain cells using PTEN Polyclonal Antibody
Western blot analysis of mouse-brain lysis using PTEN antibody.
PTEN Antibodies
PTEN for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA018964KA01HU | PTEN Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA909192 | Phospho-PTEN (Ser380/Thr382/Thr383) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA794986 | PTEN (Ab-380/382/383) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000679 | PTEN (Ab-370) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA585981 | Phospho-PTEN (Ser380) Antibody | Human, Mouse, Rat | ELISA, IHC, IF |
| CSB-PA148620 | Phospho-PTEN (Ser370) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000142 | Acetyl-PTEN (K402) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA000614 | Phospho-PTEN (S370) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003874 | PTEN Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003876 | PTEN Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA003877 | PTEN Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA003880 | PTEN Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA040052 | Phospho-PTEN (S380/T382/T383) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA040053 | Phospho-PTEN (S385) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA040056 | Phospho-PTEN (S380) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA087229 | PTEN Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA018964A380phHU | Phospho-PTEN (S380) Recombinant Monoclonal Antibody | Human | ELISA, WB |
PTEN Proteins
PTEN Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018964HU CSB-EP018964HU CSB-BP018964HU CSB-MP018964HU CSB-EP018964HU-B |
Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTEN Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018964DO CSB-EP018964DO CSB-BP018964DO CSB-MP018964DO CSB-EP018964DO-B |
Recombinant Dog Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTEN Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018964MO CSB-BP018964MO CSB-MP018964MO CSB-EP018964MO-B |
Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (Pten) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTEN Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP840549DKK CSB-EP840549DKK CSB-BP840549DKK CSB-MP840549DKK CSB-EP840549DKK-B |
Recombinant Dictyostelium discoideum Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (pteN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTEN Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP879379XBE CSB-EP879379XBE CSB-BP879379XBE CSB-MP879379XBE CSB-EP879379XBE-B |
Recombinant Xenopus laevis Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (pten) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
