PTDSS1
PTDSS1（磷脂酰絲氨酸合成酶1）是細(xì)胞內(nèi)磷脂代謝的關(guān)鍵酶，也被稱(chēng)為PSS1或PTDSS。該蛋白通過(guò)催化絲氨酸與CDP-二酰基甘油的結(jié)合反應(yīng)，在內(nèi)質(zhì)網(wǎng)中合成磷脂酰絲氨酸（PS），后者是細(xì)胞膜的重要組分。PS不僅參與膜結(jié)構(gòu)的動(dòng)態(tài)平衡，還在凋亡細(xì)胞表面暴露時(shí)觸發(fā)免疫清除信號(hào)，并與凝血因子活化、突觸可塑性等生理過(guò)程相關(guān)。近年來(lái)研究發(fā)現(xiàn)，PTDSS1基因突變與遺傳性小腦共濟(jì)失調(diào)2型（SCA2）及Lenz-Majewski綜合征相關(guān)，其表達(dá)異常可能影響神經(jīng)細(xì)胞膜穩(wěn)定性。在腫瘤領(lǐng)域，PTDSS1過(guò)表達(dá)被證實(shí)通過(guò)改變細(xì)胞膜磷脂組成促進(jìn)肝癌、乳腺癌侵襲轉(zhuǎn)移。針對(duì)該靶點(diǎn)的藥物研發(fā)尚處早期，已有研究嘗試?yán)眯》肿右种苿└蓴_PS合成通路，或通過(guò)調(diào)控PTDSS1表達(dá)增強(qiáng)化療藥物敏感性。2021年《自然·化學(xué)生物學(xué)》報(bào)道了首個(gè)選擇性靶向PTDSS1的化合物探針，為相關(guān)疾病治療提供了新思路。
熱銷(xiāo)產(chǎn)品
Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial (CSB-RP043054h)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PTDSS1 Antibody (CSB-PA04305A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: 293T whole cell lysate(20μg), K562 whole cell lysate(20μg), HepG2 whole cell lysate(20μg), MCF7 whole cell lysate(20μg
All lanes: PTDSS1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 56,39,35 kDa
Observed band size: 35 kDa
Exposure time: 60s
IHC image of CSB-PA04305A0Rb diluted at 1:150 and staining in paraffin-embedded humanpancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
PTDSS1 Antibodies
PTDSS1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA04305A0Rb | PTDSS1 Antibody | Human | ELISA,WB, IHC |
PTDSS1 Proteins
PTDSS1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018962HU CSB-EP018962HU CSB-BP018962HU CSB-MP018962HU CSB-EP018962HU-B |
Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP043054h | Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial | E.coli |
