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PSMD11

PSMD11,全稱為26S蛋白酶體調節亞基非ATP酶11,常被稱作RPN6。它是細胞內蛋白降解系統的核心組件之一,負責協助識別并處理那些需要被清除的蛋白質——比如調控細胞分裂的因子、錯誤折疊的異常蛋白等,以此維持細胞內的正常運作。PSMD11功能出現偏差時,細胞內的蛋白平衡會被打亂:要么有害蛋白積累,要么增殖相關的蛋白無法及時降解,這與肺癌、乳腺癌等癌癥的發生發展緊密相關,也可能參與神經退行性疾病的病理過程。在藥物研發領域,現有蛋白酶體藥物多針對催化部分,而針對PSMD11這類調節亞基的靶向候選物正處于早期探索階段,部分小分子能通過影響它的功能抑制腫瘤細胞增殖,為癌癥治療開辟了新的可能性。

熱銷產品

Recombinant Human 26S proteasome non-ATPase regulatory subunit 11 (PSMD11) (CSB-EP018901HU)

驗證數據

CSB-EP018901HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PSMD11 Antibody (CSB-PA00575A0Rb)

驗證數據

CSB-PA00575A0Rb

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA00575A0Rb at dilution of 1:100

CSB-PA00575A0Rb

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA00575A0Rb at dilution of 1:100

CSB-PA00575A0Rb

Immunofluorescence staining of MCF-7 cells with CSB-PA00575A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PSMD11 Antibodies

PSMD11 for Homo sapiens (Human)

PSMD11 Proteins

PSMD11 Proteins for Homo sapiens (Human)