POLQ
POLQ，即DNA聚合酶θ，別名DPOLQ、POLH、PRO0327，它是一種由POLQ基因編碼的酶，參與DNA復(fù)制和修復(fù)，尤其在DNA雙鏈斷裂修復(fù)中起作用。它在多種癌癥中高度活躍，其活性對(duì)某些癌細(xì)胞的存活至關(guān)重要。POLQ的作用機(jī)制包括填補(bǔ)DNA復(fù)制中的間隙，促進(jìn)復(fù)制繼續(xù)進(jìn)行，但這一過(guò)程容易出錯(cuò)，可能導(dǎo)致突變率增加。在BRCA缺陷的癌細(xì)胞中，POLQ的抑制可以引發(fā)合成致死，使其成為癌癥治療的潛在靶點(diǎn)。POLQ抑制劑的開(kāi)發(fā)正在進(jìn)行臨床試驗(yàn)，以評(píng)估其在治療特定類型癌癥中的潛力。
熱銷產(chǎn)品
Recombinant Human DNA polymerase theta (POLQ), partial (CSB-EP018321HU9)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
POLQ Antibodies
POLQ for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006685 | POLQ Antibody | Human | IHC, ELISA |
POLQ Proteins
POLQ Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-EP018321HU | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-BP018321HU2 | Recombinant Human DNA polymerase theta (POLQ), partial | Baculovirus |
| CSB-EP018321HU9 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-EP018321HU1 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-BP018321HU9 | Recombinant Human DNA polymerase theta (POLQ), partial | Baculovirus |
| CSB-EP018321HU9c7 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-BP018321HU1 | Recombinant Human DNA polymerase theta (POLQ), partial | Baculovirus |
| CSB-EP018321HU9k10 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-EP018321HU9a0 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
