POLQ
POLQ，即DNA聚合酶θ，別名DPOLQ、POLH、PRO0327，它是一種由POLQ基因編碼的酶，參與DNA復制和修復，尤其在DNA雙鏈斷裂修復中起作用。它在多種癌癥中高度活躍，其活性對某些癌細胞的存活至關重要。POLQ的作用機制包括填補DNA復制中的間隙，促進復制繼續進行，但這一過程容易出錯，可能導致突變率增加。在BRCA缺陷的癌細胞中，POLQ的抑制可以引發合成致死，使其成為癌癥治療的潛在靶點。POLQ抑制劑的開發正在進行臨床試驗，以評估其在治療特定類型癌癥中的潛力。
熱銷產品
Recombinant Human DNA polymerase theta (POLQ), partial (CSB-EP018321HU9)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
POLQ Antibodies
POLQ for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006685 | POLQ Antibody | Human | IHC, ELISA |
POLQ Proteins
POLQ Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP018321HU | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-BP018321HU2 | Recombinant Human DNA polymerase theta (POLQ), partial | Baculovirus |
| CSB-EP018321HU9 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-EP018321HU1 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-BP018321HU9 | Recombinant Human DNA polymerase theta (POLQ), partial | Baculovirus |
| CSB-EP018321HU9c7 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-BP018321HU1 | Recombinant Human DNA polymerase theta (POLQ), partial | Baculovirus |
| CSB-EP018321HU9k10 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
| CSB-EP018321HU9a0 | Recombinant Human DNA polymerase theta (POLQ), partial | E.coli |
