PLXNB2
PLXNB2，即神經(jīng)叢蛋白B2，別名KIAA0315、MM1、Nbla00445、PLEXB2等。它是一種跨膜受體，參與軸突導(dǎo)向和細(xì)胞遷移，響應(yīng)于信號(hào)蛋白如血管生成素。PLXNB2的作用機(jī)制包括與血管生成素結(jié)合，激活下游的RHOA信號(hào)通路，影響細(xì)胞骨架的重組和細(xì)胞遷移。PLXNB2在神經(jīng)系統(tǒng)發(fā)育、腫瘤發(fā)生發(fā)展、以及細(xì)胞遷移和增殖等過(guò)程中發(fā)揮重要作用。例如，它在急性髓系白血病（AML）中的過(guò)表達(dá)與不良預(yù)后相關(guān)，可能作為潛在的生物標(biāo)志物和治療靶點(diǎn)。此外，PLXNB2還與癌癥肝轉(zhuǎn)移的形成有關(guān)，其在肝細(xì)胞中的表達(dá)增加可以促進(jìn)腸癌、胰腺癌和黑色素瘤等癌癥的肝轉(zhuǎn)移。
熱銷產(chǎn)品
Recombinant Human Plexin-B2 (PLXNB2), partial (CSB-EP018223HUe1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PLXNB2 Antibody (CSB-PA018223ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: PLXNB2 antibody IgG at 2.39μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 205 kDa
Observed band size: 205 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA018223ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018223ESR1HU at dilution of 1:100
PLXNB2 Antibodies
PLXNB2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018223GA01HU | PLXNB2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA124601 | PLXNB2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA347467 | PLXNB2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA018223ESR1HU | PLXNB2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA018223LA01HU | PLXNB2 Antibody | Human | ELISA, WB |
| CSB-PA018223LB01HU | PLXNB2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018223LC01HU | PLXNB2 Antibody，F(xiàn)ITC conjugated | Human | |
| CSB-PA018223LD01HU | PLXNB2 Antibody， Biotin conjugated | Human | ELISA |
PLXNB2 Proteins
PLXNB2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP018223HU CSB-EP018223HU CSB-BP018223HU CSB-MP018223HU CSB-EP018223HU-B |
Recombinant Human Plexin-B2 (PLXNB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018223HUe1 | Recombinant Human Plexin-B2 (PLXNB2), partial | E.coli |
