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PLK4

Serine/threonine-protein kinase PLK4 is a protein in humans that is encoded by PLK4 gene. Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors.

PLK4 Antibodies

PLK4 for Homo sapiens (Human)

PLK4 Proteins

PLK4 Proteins for Bos taurus (Bovine)

PLK4 Proteins for Rattus norvegicus (Rat)

PLK4 Proteins for Homo sapiens (Human)

PLK4 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

PLK4 Proteins for Pongo abelii (Sumatran orangutan)

PLK4 Proteins for Mus musculus (Mouse)

PLK4 Proteins for Xenopus laevis (African clawed frog)

PLK4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)



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