PIP5K1A

PIP5K1A，全稱為 phosphatidylinositol-4-phosphate 5-kinase type I, alpha，常見別名為 PIP5K1A lipid kinase 或 phosphatidylinositol-4-phosphate 5-kinase 1 alpha。該蛋白參與細胞內磷脂酰肌醇代謝，通過催化磷脂酰肌醇 4-磷酸 (PtdIns(4)P) 生成磷脂酰肌醇 4,5-二磷酸 (PtdIns(4,5)P2) 來調節細胞膜脂質組成和信號轉導。PIP5K1A 蛋白的表達與多種細胞過程相關，包括細胞增殖、分化、遷移和凋亡等。研究表明，PIP5K1A 蛋白在腫瘤細胞中表達異常，并與腫瘤的發生發展密切相關。例如，PIP5K1A 蛋白在肝細胞癌中高表達，促進腫瘤細胞增殖并預測患者預后不良。此外，PIP5K1A 蛋白還與鐵死亡過程相關，通過穩定核因子紅細胞 2 相關因子2 (NRF2) 蛋白水平來抑制鐵死亡。針對 PIP5K1A 蛋白的藥物研發正在積極開展，例如，PIP5K1A 特異性抑制劑 ISA-2011B 可有效抑制腫瘤生長并增強腫瘤細胞對索拉非尼的敏感性，展現出良好的應用前景。

熱銷產品

TUT1 Antibody (CSB-PA046708)

驗證數據

Western blot analysis of extracts from 3T3 cells, using TUT1 antiobdy.

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using TUT1 antibody.

PIP5K1A Antibody

PIP5K1A Protein

PIP5K1A Antibodies

PIP5K1A for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA018025GA01HU	PIP5K1A Antibody	Human,Mouse,Rat	ELISA,WB,IF,IP
CSB-PA046708	TUT1 Antibody	Human	ELISA,WB,IHC
CSB-PA050066	TUT1 Antibody	Human	WB, IHC, ELISA
CSB-PA960186	PIP5K1A Antibody	Human	ELISA,WB,IHC
CSB-PA094535	PIP5K1A Antibody	Human	ELISA,WB,IHC
CSB-PA859110ESR1HU	PIP5K1A Antibody	Human, Mouse	ELISA, WB, IHC

PIP5K1A Proteins

PIP5K1A Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP018025MO CSB-EP018025MO CSB-BP018025MO CSB-MP018025MO CSB-EP018025MO-B	Recombinant Mouse Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Pip5k1a)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PIP5K1A Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP859110HU CSB-EP859110HU CSB-BP859110HU CSB-MP859110HU CSB-EP859110HU-B	Recombinant Human Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP884477HU CSB-EP884477HU CSB-BP884477HU CSB-MP884477HU CSB-EP884477HU-B	Recombinant Human Speckle targeted PIP5K1A-regulated poly (A) polymerase (TUT1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli