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PIK3CA

PIK3CA,即磷脂酰肌醇4,5-二磷酸3-激酶催化亞基α,別名PI3K-alpha。PIK3CA由人類PIK3CA基因編碼,該基因位于3號染色體的q26.3區(qū)域,包含21個(gè)外顯子,編碼1068種氨基酸,產(chǎn)生一組長124kD的蛋白。PIK3CA的作用機(jī)制涉及催化膜脂磷脂酰肌醇-4,5-二磷酸[PI(4,5)P2]到第二信使PI(3,4,5)P3(也被稱為PIP3)的轉(zhuǎn)化,激活A(yù)KT-mTOR信號通路,促進(jìn)細(xì)胞存活、增殖、生長和運(yùn)動。PIK3CA是癌癥中最常見的突變基因之一,其激活突變在乳腺癌、子宮內(nèi)膜癌、膀胱癌、結(jié)腸直腸癌等多種癌癥中均有發(fā)現(xiàn),參與腫瘤發(fā)生、進(jìn)展及轉(zhuǎn)移定植。PIK3CA基因的突變導(dǎo)致PI3K/AKT通路水平上調(diào),進(jìn)而參與腫瘤發(fā)生。

熱銷產(chǎn)品

Recombinant Human?Phosphatidylinositol?4,5-bisphosphate?3-kinase?catalytic?subunit?alpha?isoform (PIK3CA), partial (CSB-EP017998HU)

驗(yàn)證數(shù)據(jù)

CSB-EP017998HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PIK3CA Recombinant Monoclonal Antibody (CSB-RA578819A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA578819A0HU

Western Blot
Positive WB detected in: Jurkat whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate
All lanes: PIK3CA antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 125 kDa
Observed band size: 110 kDa

CSB-RA578819A0HU

Immunofluorescence staining of Hela Cells with CSB-RA578819A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

PIK3CA Antibodies

PIK3CA for Homo sapiens (Human)

PIK3CA Proteins

PIK3CA Proteins for Bos taurus (Bovine)

PIK3CA Proteins for Homo sapiens (Human)

PIK3CA Proteins for Mus musculus (Mouse)

PIK3CA ELISA Kit

PIK3CA ELISA Kit for Homo sapiens (Human)

PIK3CA ELISA Kit for Mus musculus (Mouse)



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