PDIA3

PDIA3，即蛋白質二硫鍵異構酶A3（Protein disulfide-isomerase A3），別名58 kDa glucose-regulated protein、58 kDa microsomal protein (p58)、Disulfide isomerase ER-60。它屬于蛋白質二硫鍵異構酶(PDI)家族的成員，是一種在內質網中催化二硫鍵形成的酶，對蛋白質折疊和質量控制起著至關重要的作用。PDIA3作為分子伴侶，參與蛋白質的正確折疊、組裝和分泌，尤其在細胞應激反應中高度表達，能夠攔截與內質網應激相關的凋亡性細胞死亡。PDIA3在生物學上的意義非常廣泛，其表達在約70%的癌癥中升高，并且與腫瘤細胞的低侵襲性、存活和轉移能力有關。PDIA3還與免疫激活標志物、癌癥免疫細胞浸潤和免疫調節(jié)劑顯著相關，特別是能夠顯著預測抗PDL1治療反應。此外，PDIA3在T細胞受體(TCR)信號通路中具有調控作用，能夠促進T細胞的活化，參與調節(jié)T細胞TCR信號通路，影響ZAP70蛋白的磷酸化水平、CD69表達和IL-2的分泌，以及NF-κB信號通路。因此，PDIA3不僅在蛋白質合成、降解和分泌中發(fā)揮作用，塑造腫瘤微環(huán)境，還是癌癥預后和免疫治療反應的有力生物標志物，具有作為抗癌治療靶點的潛力。

熱銷產品

Recombinant Human Protein disulfide-isomerase A3 (PDIA3) (CSB-EP017720HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PDIA3 Antibody (CSB-PA005150)

驗證數據

Western Blot analysis of A549 HT29 K562 cells using ERp57 Polyclonal Antibody

Human protein disulfide-isomerase A3,PDIA3 ELISA Kit (CSB-E09798h)

驗證數據

貨號：CSB-E09798h

規(guī)格：96T/48T

靈敏度：0.31 ng/mL

檢測范圍：1.25 ng/mL-80 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PDIA3 Antibody

PDIA3 Protein

PDIA3 ELISA Kit

PDIA3 Antibodies

PDIA3 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA06284A0Rb	PDIA3 Antibody	Human	ELISA
CSB-PA017720GA01HU	PDIA3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA005150	PDIA3 Antibody	Human,Mouse,Rat	WB, ELISA

PDIA3 Proteins

PDIA3 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP017720RA CSB-EP017720RA CSB-BP017720RA CSB-MP017720RA CSB-EP017720RA-B	Recombinant Rat Protein disulfide-isomerase A3 (Pdia3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP017720MO CSB-EP017720MO CSB-BP017720MO CSB-MP017720MO CSB-EP017720MO-B	Recombinant Mouse Protein disulfide-isomerase A3 (Pdia3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP017720HU CSB-BP017720HU CSB-MP017720HU CSB-EP017720HU-B	Recombinant Human Protein disulfide-isomerase A3 (PDIA3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP017720HU	Recombinant Human Protein disulfide-isomerase A3 (PDIA3)	E.coli

PDIA3 Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP017720BO CSB-EP017720BO CSB-BP017720BO CSB-MP017720BO CSB-EP017720BO-B	Recombinant Bovine Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Papio hamadryas (Hamadryas baboon)

產品貨號	產品名稱	來源
CSB-YP017720ERJ CSB-EP017720ERJ CSB-BP017720ERJ CSB-MP017720ERJ CSB-EP017720ERJ-B	Recombinant Papio hamadryas Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Mesocricetus auratus (Golden hamster)

產品貨號	產品名稱	來源
CSB-YP017720MRG CSB-EP017720MRG CSB-BP017720MRG CSB-MP017720MRG CSB-EP017720MRG-B	Recombinant Mesocricetus auratus Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

產品貨號	產品名稱	來源
CSB-YP684159DSU CSB-EP684159DSU CSB-BP684159DSU CSB-MP684159DSU CSB-EP684159DSU-B	Recombinant Chlorocebus aethiops Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Pongo abelii (Sumatran orangutan)

產品貨號	產品名稱	來源
CSB-YP712990PYX CSB-EP712990PYX CSB-BP712990PYX CSB-MP712990PYX CSB-EP712990PYX-B	Recombinant Pongo abelii Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP810332CH CSB-EP810332CH CSB-BP810332CH CSB-MP810332CH CSB-EP810332CH-B	Recombinant Chicken Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli