PDHA1
PDHA1，全稱為丙酮酸脫氫酶復合體E1亞基α1，常被簡稱為PDHE1-α1。它是細胞能量代謝中的核心分子之一，能推動糖代謝產生的丙酮酸轉化為乙酰輔酶A，這是糖酵解與三羧酸循環之間的關鍵銜接步驟，直接關系到細胞能否高效生成能量。
PDHA1功能異常，易引發丙酮酸脫氫酶缺乏癥。患者多出現乳酸水平異常升高、神經發育遲緩、運動能力障礙等表現，部分嚴重病例還可能伴隨腦損傷、器官功能紊亂等問題。目前針對這類疾病的干預手段包括補充硫辛酸等輔酶類物質以改善酶活性，也在探索基因治療或小分子藥物修復蛋白功能。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PDHA1 Recombinant Monoclonal Antibody (CSB-RA440123A0HU)
驗證數據
Flow cytometric analysis of PDHA1 expression in HepG2 cells using PDHA1 antibody. Green, isotype control; red, PDHA1.
Immunocytochemical staining of HepG2 cells with PDHA1 antibody. Nuclei were stained blue with DAPI; PDHA1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Western blotting analysis using PDHA1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PDHA1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
PDHA1 Antibody (CSB-PA017715LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017715LA01HU at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using CSB-PA017715LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PDHA1 Antibodies
PDHA1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017715GA01HU | PDHA1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA247984 | PDHA1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA003727 | PDHA1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA017715LA01HU | PDHA1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA017715LD01HU | PDHA1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA017715LC01HU | PDHA1 Antibody, FITC conjugated | Human | |
| CSB-PA017715LB01HU | PDHA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA189996A0HU | PDHA1 Recombinant Monoclonal Antibody | Human, Rat | ELISA, WB, IHC, FC |
| CSB-RA440123A0HU | PDHA1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
PDHA1 Proteins
PDHA1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017715RA CSB-EP017715RA CSB-BP017715RA CSB-MP017715RA CSB-EP017715RA-B |
Recombinant Rat Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (Pdha1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDHA1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017715MO CSB-BP017715MO CSB-MP017715MO CSB-EP017715MO-B |
Recombinant Mouse Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (Pdha1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDHA1 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017715PI CSB-EP017715PI CSB-BP017715PI CSB-MP017715PI CSB-EP017715PI-B |
Recombinant Pig Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDHA1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017715DO CSB-EP017715DO CSB-BP017715DO CSB-MP017715DO CSB-EP017715DO-B |
Recombinant Dog Pyruvate dehydrogenase E1 component subunit alpha, somatic form (PDHA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDHA1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017715HU CSB-BP017715HU CSB-MP017715HU CSB-EP017715HU-B |
Recombinant Human Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017715HUb1 | Recombinant Human Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), partial | E.coli |
| CSB-EP017715HUc0 | Recombinant Human Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), partial | E.coli |
| CSB-EP017715HU | Recombinant Human Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), partial | E.coli |
| CSB-EP017715HUc7 | Recombinant Human Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), partial | E.coli |
| CSB-EP017715HUa2 | Recombinant Human Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), partial | E.coli |
PDHA1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017715BO CSB-EP017715BO CSB-BP017715BO CSB-MP017715BO CSB-EP017715BO-B |
Recombinant Bovine Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDHA1 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP397897EQV CSB-EP397897EQV CSB-BP397897EQV CSB-MP397897EQV CSB-EP397897EQV-B |
Recombinant Pan troglodytes Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDHA1 Proteins for Pongo abelii (Sumatran orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP728879PYX CSB-EP728879PYX CSB-BP728879PYX CSB-MP728879PYX CSB-EP728879PYX-B |
Recombinant Pongo abelii Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDHA1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP808486MOV CSB-EP808486MOV CSB-BP808486MOV CSB-MP808486MOV CSB-EP808486MOV-B |
Recombinant Macaca fascicularis Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
