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PAK1

PAK1,即p21活化激酶1,別名包括ADRB2、 Alpha PAK、MGC130001、p21 activated kinase 1。它是一種絲氨酸/蘇氨酸激酶,由人體細胞自身的PAK1基因編碼,屬于PAK家族成員之一。PAK1的作用機制涉及響應小G蛋白RAC1和CDC42的信號,通過磷酸化多種底物蛋白,調控細胞的增殖、遷移、凋亡等關鍵過程。PAK1在細胞信號傳導、腫瘤發生、神經發育、免疫反應等多種生物學過程中發揮重要作用,其異常活化與腫瘤進展、轉移及某些神經退行性疾病相關,是藥物開發中的潛在靶點。

熱銷產品

Recombinant Human Serine/threonine-protein kinase PAK 1 (PAK1) (CSB-EP613382HU)

驗證數據

CSB-EP613382HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PAK1 Recombinant Monoclonal Antibody (CSB-RA287160A0HU)

驗證數據

CSB-RA287160A0HU

Western Blot
Positive WB detected in: MCF7 whole cell lysate, JK whole cell lysate, K562 whole cell lysate, A549 whole cell lysate,ntera2 whole cell lysate, Mouse Heart tissue lysate, Mouse Skeletal Muscle tissue lysate, Mouse Brain tissue lysate, Rat Brain tissue lysate
All lanes: PAK1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61 kDa
Observed band size: 61 kDa

CSB-RA287160A0HU

Immunofluorescence staining of Hela cell with CSB-RA287160A0HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PAK1 Antibodies

PAK1 for Homo sapiens (Human)

PAK1 Proteins

PAK1 Proteins for Rattus norvegicus (Rat)

PAK1 Proteins for Mus musculus (Mouse)

PAK1 Proteins for Bos taurus (Bovine)

PAK1 Proteins for Homo sapiens (Human)



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