P2RX7
P2RX7全稱為嘌呤能受體P2X配體門控離子通道7，也被稱為P2X7受體或P2X7R。P2RX7廣泛分布于免疫細(xì)胞、神經(jīng)膠質(zhì)細(xì)胞等組織，其功能與細(xì)胞外三磷酸腺苷（ATP）濃度變化密切相關(guān)。當(dāng)ATP與受體結(jié)合后，會(huì)觸發(fā)離子通道開放，介導(dǎo)鉀離子外流及鈣離子內(nèi)流，進(jìn)而激活下游炎癥反應(yīng)通路。這種特性使其在NLRP3炎癥小體激活、細(xì)胞焦亡等病理過程中發(fā)揮關(guān)鍵作用，并與細(xì)胞增殖、凋亡調(diào)控存在復(fù)雜關(guān)聯(lián)。
P2RX7異常表達(dá)與多種疾病密切相關(guān)，包括類風(fēng)濕性關(guān)節(jié)炎、克羅恩病等自身免疫性疾病，阿爾茨海默病、多發(fā)性硬化等神經(jīng)系統(tǒng)病變，以及乳腺癌、黑色素瘤等惡性腫瘤的進(jìn)展。近年來針對(duì)該受體的藥物開發(fā)取得突破，如選擇性拮抗劑JNJ-54175446已完成銀屑病二期臨床試驗(yàn)，AZD9056在慢性咳嗽治療中顯示出潛力。基于P2RX7的激活特性，科研人員正在探索其在腫瘤免疫治療中的增效作用，為精準(zhǔn)醫(yī)療提供新方向。
熱銷產(chǎn)品
Recombinant Human P2X purinoceptor 7 (P2RX7), partial (CSB-EP859103HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
P2RX7 Antibody (CSB-PA859103LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of Hela cells with CSB-PA859103LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human P2X purinoceptor 7(P2RX7) ELISA kit (CSB-EL017325HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL017325HU
規(guī)格：96T/48T
靈敏度：6.25 pg/mL
檢測范圍：25 pg/mL-1600 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
P2RX7 Antibodies
P2RX7 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017325GA01HU | P2RX7 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA859103LA01HU | P2RX7 Antibody | Human | ELISA, IF |
| CSB-PA859103LB01HU | P2RX7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA859103LC01HU | P2RX7 Antibody, FITC conjugated | Human | |
| CSB-PA859103LD01HU | P2RX7 Antibody, Biotin conjugated | Human | ELISA |
P2RX7 Proteins
P2RX7 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP731066RA CSB-EP731066RA CSB-BP731066RA CSB-MP731066RA CSB-EP731066RA-B |
Recombinant Rat P2X purinoceptor 7 (P2rx7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
P2RX7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP859103HU CSB-BP859103HU CSB-MP859103HU CSB-EP859103HU-B |
Recombinant Human P2X purinoceptor 7 (P2RX7), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP859103HU | Recombinant Human P2X purinoceptor 7 (P2RX7), partial | E.coli |
P2RX7 ELISA Kit
P2RX7 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL017325HU | Human P2X purinoceptor 7(P2RX7) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |
