OTUD3
OTUD3，即OTU結(jié)構(gòu)域含蛋白3，別名OTUD7B、JAMM-2、JAMM2等。它是一種由OTUD3基因編碼的蛋白質(zhì)，屬于OTU蛋白酶家族成員，在細胞內(nèi)具有去泛素化酶活性。OTUD3的作用機制涉及其OTU結(jié)構(gòu)域，該結(jié)構(gòu)域賦予了它特異性去除蛋白質(zhì)上泛素化修飾的能力，參與調(diào)控蛋白質(zhì)的穩(wěn)定性和信號傳導過程。OTUD3的功能異常與多種疾病有關(guān)，包括某些類型的癌癥、神經(jīng)退行性疾病等。研究表明，OTUD3通過去泛素化修飾影響p53蛋白的穩(wěn)定性，進而影響細胞對DNA損傷的響應。此外，OTUD3還在免疫細胞中發(fā)揮作用，調(diào)節(jié)炎癥反應和細胞因子的產(chǎn)生。因此，OTUD3是細胞生物學和疾病研究中的一個重要分子靶點。
熱銷產(chǎn)品
OTUD3 Antibody (CSB-PA719399LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: U251 whole cell lysate, U87 whole cell lysate
All lanes: OTUD3 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa
Immunofluorescence staining of U251 cells with CSB-PA719399LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
OTUD3 Antibodies
OTUD3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA719399LA01HU | OTUD3 Antibody | Human | ELISA, WB, IF |
| CSB-PA719399LB01HU | OTUD3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA719399LC01HU | OTUD3 Antibody, FITC conjugated | Human | |
| CSB-PA719399LD01HU | OTUD3 Antibody, Biotin conjugated | Human | ELISA |
OTUD3 Proteins
OTUD3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP719399HU CSB-EP719399HU CSB-BP719399HU CSB-MP719399HU CSB-EP719399HU-B |
Recombinant Human OTU domain-containing protein 3 (OTUD3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
