NRG1，即神經(jīng)調(diào)節(jié)蛋白1，別名HRG、NDF、GGF。這是一種由人類NRG1基因編碼的蛋白質(zhì)，屬于表皮生長(zhǎng)因子（EGF）家族。NRG1主要是通過(guò)其異構(gòu)體與ErbB家族受體結(jié)合，激活多重下游信號(hào)通路，如PI3K/Akt、MAPK/ERK等，從而促進(jìn)細(xì)胞增殖、分化，抑制細(xì)胞凋亡，調(diào)節(jié)能量利用，并增強(qiáng)血管生成。NRG1的表達(dá)和功能異常與多種疾病的發(fā)生發(fā)展相關(guān)，包括腫瘤、心血管疾病、神經(jīng)精神疾病等。在腫瘤領(lǐng)域，NRG1基因融合是一種新興的、潛在的致癌驅(qū)動(dòng)因素，與多種腫瘤的發(fā)生發(fā)展相關(guān)，如非小細(xì)胞肺癌、腎癌、甲狀腺癌等。在心血管疾病中，NRG1/ErbB信號(hào)通路在心臟的發(fā)育、心肌增殖分化及心臟傳導(dǎo)系統(tǒng)的形成過(guò)程中起到了重要作用，并在心血管急慢性疾病中對(duì)心肌細(xì)胞具有保護(hù)功能。因此，NRG1被認(rèn)為是這些疾病潛在的治療靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active) (CSB-MP016077HU1(F6))

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized NRG1 at 2 μg/ml can bind human ERBB3(CSB-MP007765HU), the EC₅₀ is 18.24-23.66 ng/ml.

Activity
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of MCF-7 cells is 2.626-7.598 ng/mL.

The purity of NRG1 was greater than 95% as determined by SEC-HPLC