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NFKB2

Nuclear factor NF-kappa-B p100 subunit is a protein in humans that is encoded by NFKB2 gene. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors.

NFKB2 Antibodies

NFKB2 for Homo sapiens (Human)

NFKB2 Proteins

NFKB2 Proteins for Gallus gallus (Chicken)

NFKB2 Proteins for Xenopus laevis (African clawed frog)

NFKB2 Proteins for Mus musculus (Mouse)



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