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NCR3

NCR3,全稱為Natural cytotoxicity triggering receptor 3,也被稱為NKp30,是一種存在于自然殺傷細胞表面的跨膜蛋白。它屬于免疫球蛋白超家族,能夠識別并結合腫瘤細胞或病毒感染細胞表面的多種非MHC配體,如硫酸乙酰肝素糖胺聚糖(HS GAGs)和B7-H6等,從而激活NK細胞的細胞毒性作用,直接裂解靶細胞。NCR3的激活能夠調節NK細胞的細胞因子分泌功能,如干擾素-γ(IFN-γ)和腫瘤壞死因子-α(TNF-α)等,這些細胞因子能夠進一步增強免疫反應,清除感染或腫瘤細胞。NCR3在腫瘤免疫逃逸和抗病毒免疫中發揮著重要作用,其功能狀態可能影響腫瘤的發生發展以及病毒感染的慢性化進程。目前,針對NCR3的治療策略主要包括使用單克隆抗體增強NCR3與配體的結合活性,或通過基因治療上調NK細胞表面NCR3的表達,以增強NK細胞的抗腫瘤活性。此外,部分小分子及生物制劑已進入臨床驗證階段,未來有望為腫瘤和感染性疾病患者帶來新的治療選擇。

熱銷產品

Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial (Active) (CSB-MP015551HU1)

驗證數據

CSB-MP015551HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP015551HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human NCR3 at 5 μg/ml can bind human NCR3LG1(CSB-MP737873HU-B). The EC50 is 111.3-303.1 ng/mL.

CSB-MP015551HU1

The purity of NCR3 was greater than 95% as determined by SEC-HPLC

NCR3 Antibody (CSB-PA015551LA01HU)

驗證數據

CSB-PA015551LA01HU

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA015551LA01HU at dilution of 1:100

CSB-PA015551LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA015551LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

NCR3 Antibodies

NCR3 for Homo sapiens (Human)

NCR3 Proteins

NCR3 Proteins for Homo sapiens (Human)

NCR3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

NCR3 Proteins for Pan troglodytes (Chimpanzee)

NCR3 Proteins for Rattus norvegicus (Rat)

NCR3 Proteins for Macaca mulatta (Rhesus macaque)



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