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NCAPG2

NCAPG2,全稱為非SMC凝縮蛋白II復合體亞基G2,也被稱為染色體相關蛋白G2(CAP-G2)或亮氨酸 zipper 蛋白5(LUZP5)。該蛋白參與染色體凝縮和分離過程,確保細胞分裂時染色體正確分配。它主要在細胞周期的S期和G2/M期表達,其核心功能是幫助染色體在細胞分裂前正確凝縮,防止DNA纏結和斷裂。NCAPG2蛋白的表達水平異常可能影響基因組穩定性,并與多種癌癥的發生密切相關,如乳腺癌、肺癌和結直腸癌。研究發現,NCAPG2過表達會加速細胞周期進程,促進腫瘤細胞增殖和轉移,而降低其表達則會導致染色體凝縮缺陷,引發細胞有絲分裂異常甚至凋亡。此外,NCAPG2還參與DNA損傷修復,其表達水平異常可能影響基因組穩定性。目前,針對NCAPG2的研究主要集中在癌癥治療領域,探索通過調節其表達或功能來抑制腫瘤生長的可能性。

熱銷產品

NCAPG2 Antibody (CSB-PA572077)

驗證數據

CSB-PA572077

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA572077(NCAPG2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA572077

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA572077(NCAPG2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

NCAPG2 Antibodies

NCAPG2 for Homo sapiens (Human)

NCAPG2 Proteins

NCAPG2 Proteins for Homo sapiens (Human)