MUC1

MUC1，即黏蛋白1，別名MAM6、EMA等。它是一種高度糖基化的I型跨膜蛋白，由MUC1基因編碼，該基因位于染色體1q22上，通過選擇性剪接可產(chǎn)生多種亞型。MUC1蛋白主要包括細(xì)胞外區(qū)域、跨膜區(qū)和細(xì)胞質(zhì)區(qū)，其中細(xì)胞外區(qū)域包含大量可發(fā)生O-糖基化的絲氨酸和蘇氨酸殘基，這些糖基化對(duì)于MUC1的生物學(xué)功能至關(guān)重要。MUC1在生物學(xué)上的意義非常廣泛，它在正常上皮細(xì)胞中作為保護(hù)性屏障，防止外界環(huán)境及微生物的侵害。然而，在腫瘤細(xì)胞中，MUC1的表達(dá)量通常會(huì)增高，并且其結(jié)構(gòu)和糖基化水平也會(huì)發(fā)生改變。這些改變可能導(dǎo)致新的抗原表位的暴露，為腫瘤的診斷和治療提供了潛在的靶點(diǎn)。MUC1還參與了多種信號(hào)通路的調(diào)控，包括MAPK、PI3K/Akt和Wnt路徑，這些信號(hào)通路在腫瘤細(xì)胞代謝、細(xì)胞凋亡、上皮間質(zhì)轉(zhuǎn)化和遠(yuǎn)處轉(zhuǎn)移中發(fā)揮重要作用。MUC1的異常表達(dá)與腫瘤的侵襲性和轉(zhuǎn)移能力密切相關(guān)，使其成為腫瘤治療和診斷中的一個(gè)重要靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Mucin-1 (MUC1) (CSB-EP015215HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MUC1 Antibody (CSB-PA11319A0Rb)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA11319A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA11319A0Rb at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA11319A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

MUC1 Antibody

MUC1 Protein

MUC1 ELISA Kit

MUC1 Antibodies

MUC1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA11319A0Rb	MUC1 Antibody	Human	ELISA, IHC, IF
CSB-PA11319C0Rb	MUC1 Antibody, FITC conjugated	Human
CSB-PA015215GA01HU	MUC1 Antibody	Human	ELISA,WB,IHC
CSB-PA11319B0Rb	MUC1 Antibody, HRP conjugated	Human	ELISA
CSB-PA11319D0Rb	MUC1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA150023	Phospho-MUC1 (Tyr1229) Antibody	Human	ELISA,WB,IHC,IF
CSB-PA003334	MUC1 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA006277	MUC1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA010263	Phospho-MUC1 (Y1229) Antibody	Human	WB, IHC, IF, ELISA
CSB-PA010272	Phospho-MUC1 (Y1243) Antibody	Human,Mouse	IHC, ELISA
CSB-PA010274	Phospho-MUC1 (S1227) Antibody	Human	IHC, ELISA
CSB-PA010276	MUC1 Antibody	Human	IHC, ELISA
CSB-PA010277	MUC1 Antibody	Human	IHC, IF, ELISA
CSB-PA010279	MUC1 Antibody	Human,Mouse	IHC, IF, ELISA
CSB-PA141385	MUC1 Antibody	Human	ELISA,IHC
CSB-PA114224	MUC1 Antibody	Human	ELISA,WB,IHC
CSB-PA692815	MUC1 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA583379	MUC1 Antibody	Human,Mouse	ELISA,IHC

MUC1 Proteins

MUC1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-BP312543MO CSB-MP312543MO CSB-EP312543MO-B	Recombinant Mouse Mucin-1 (Muc1), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MUC1 Proteins for Hylobates lar (Common gibbon)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP645848HXW CSB-EP645848HXW CSB-BP645848HXW CSB-MP645848HXW CSB-EP645848HXW-B	Recombinant Hylobates lar Mucin-1 (MUC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MUC1 Proteins for Mesocricetus auratus (Golden hamster)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP726652MRG CSB-EP726652MRG CSB-BP726652MRG CSB-MP726652MRG CSB-EP726652MRG-B	Recombinant Mesocricetus auratus Mucin-1 (MUC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MUC1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP848794BO CSB-EP848794BO CSB-BP848794BO CSB-MP848794BO CSB-EP848794BO-B	Recombinant Bovine Mucin-1 (MUC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MUC1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-MP015215HU3-B	Recombinant Human Mucin-1(MUC1),partial,Biotinylated	Mammalian cell
CSB-MP015215HU2	Recombinant Human Mucin-1 (MUC1), partial	Mammalian cell